Linked Life Data

18508566

Source:http://linkedlifedata.com/resource/pubmed/id/18508566

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-5-29
pubmed:abstractText
Cell cycle checkpoints are pivotal mechanisms safeguarding genome stability. Cells that harbor defects in checkpoints are predisposed to genome instability and neoplastic transformation. Two structurally-unrelated protein kinases, CHK1 and CHK2, are implicated in several major checkpoints of the cell cycle, providing a crucial linkage between the upstream sensors of the checkpoints and the cell cycle engine. Variations of the ATM/ATR-CHK1/CHK2-CDC25-CDK axis underlie the molecular basis of the replication checkpoint, the intra-S phase checkpoint, and the G2 DNA damage checkpoint. Although some aspects of the pathway remain contentious, the ATM/ATR-CHK1/CHK2-p53-p21CIP1/WAF1-CDK axis is believed to play an important role in the G1 DNA damage checkpoint. Recent data also reveal that CHK1 may play a role in the spindle-assembly checkpoint. Finally, CHK1 and CHK2 are implicated in linking the cell cycle to diverse processes such as senescence and the circadian cycle. In this review article, we provide an overview of how the multi-tasking nature of CHK1 and CHK2 is achieved in vertebrate cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5016-29
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability.
pubmed:affiliation
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong.
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural