Linked Life Data

18508544

Source:http://linkedlifedata.com/resource/pubmed/id/18508544

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-5-29
pubmed:abstractText
Diabetes mellitus (DM) is an epidemic medical challenge that threatens the health and life quality of people worldwide. DM impairs metabolic, neural and vascular function and thus has profound impacts on different systems and organs in the body. Though continuous endeavour has been made to study its etiology and mechanisms, no cure for DM has yet been found. DM development may be multi-factorial. The skeletal muscle is one of the most important systems, involved in the development of DM, and affected by insulin. DM induces diverse functional, metabolic, and structural changes in the skeletal muscle. DM reduces the functional capacity of skeletal muscle leading to muscle weakness, causes metabolic disturbance characterized by reduced cellular glucose uptake and fatty acid oxidation, and structural changes with muscle atrophy, augmented lipid deposition, decreased mitochondria as well as muscle fiber transformation. DM-induced changes in the skeletal muscle seem to be dependent on types and severity of DM as well as on muscle fibers. The central mechanism underlying these changes is impaired insulin action in the skeletal muscle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4765-94
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Muscular response and adaptation to diabetes mellitus.
pubmed:affiliation
Department of Endocrinology, ZhongDa hospital, Southeast University, Nanjing, People's Republic of China.
pubmed:publicationType
Journal Article, Review