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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1991-5-31
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pubmed:abstractText |
Calcium influx in response to extracellular signals can modulate gene transcription. A constitutive, calcium/calmodulin-independent mutant of type II calcium/calmodulin-dependent protein kinase was capable of increasing the transcription rate of specific genes independently of protein kinase C activation. This increase was mediated by transferable cis-active elements capable of binding the transcription factor CAAT/enhancer binding protein. Therefore, the activation of type II calcium/calmodulin-dependent protein kinase in response to stimuli that increase intracellular calcium is proposed to represent a distinct second messenger pathway in calcium-mediated regulation of gene transcription.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-1703274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-1703275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2157471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2158811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2162838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-22932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2426600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2496129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2540166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2544878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2549638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2550324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2573431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2619995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2673888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2725492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2831625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2850264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2852025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2859595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2902928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2926401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-2985953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-3014651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-3029568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-3034433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-3156376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-3221879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-3398840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-3463433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-3475713,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-3742595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-3821727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-3918029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-4074698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-6294651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1850836-6834039
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3710-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1850836-Animals,
pubmed-meshheading:1850836-Avian Sarcoma Viruses,
pubmed-meshheading:1850836-Base Sequence,
pubmed-meshheading:1850836-Calcium,
pubmed-meshheading:1850836-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:1850836-Calmodulin,
pubmed-meshheading:1850836-DNA Mutational Analysis,
pubmed-meshheading:1850836-Gene Expression Regulation,
pubmed-meshheading:1850836-Molecular Sequence Data,
pubmed-meshheading:1850836-Molecular Weight,
pubmed-meshheading:1850836-Phosphorylation,
pubmed-meshheading:1850836-Protein Kinases,
pubmed-meshheading:1850836-Rats,
pubmed-meshheading:1850836-Recombinant Proteins,
pubmed-meshheading:1850836-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:1850836-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:1850836-Transcription, Genetic
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pubmed:year |
1991
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pubmed:articleTitle |
Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation.
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pubmed:affiliation |
Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla 92093-0648.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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