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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6320
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pubmed:dateCreated |
1991-5-31
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pubmed:abstractText |
Nerve growth factor (NGF) interacts with two different low-affinity receptors that can be distinguished by affinity crosslinking. Reconstitution experiments by membrane fusion and transient transfection into heterologous cells indicate that high-affinity NGF binding requires coexpression and binding to both the low-affinity NGF receptor and the tyrosine kinase trk gene product. These studies reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
350
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pubmed:geneSymbol |
trk
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
678-83
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1850821-Animals,
pubmed-meshheading:1850821-Cell Line,
pubmed-meshheading:1850821-Cell Membrane,
pubmed-meshheading:1850821-Cross-Linking Reagents,
pubmed-meshheading:1850821-Kinetics,
pubmed-meshheading:1850821-Membrane Fusion,
pubmed-meshheading:1850821-Models, Biological,
pubmed-meshheading:1850821-Nerve Growth Factors,
pubmed-meshheading:1850821-Protein-Tyrosine Kinases,
pubmed-meshheading:1850821-Proto-Oncogene Proteins,
pubmed-meshheading:1850821-Proto-Oncogenes,
pubmed-meshheading:1850821-Receptor, trkA,
pubmed-meshheading:1850821-Receptors, Cell Surface,
pubmed-meshheading:1850821-Receptors, Nerve Growth Factor,
pubmed-meshheading:1850821-Transfection
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pubmed:year |
1991
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pubmed:articleTitle |
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor.
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pubmed:affiliation |
Department of Medicine, Cornell University Medical College, New York, New York 10021.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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