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pubmed-article:18507845pubmed:abstractTextThe endogenous pain-relieving system depends in part on the regulation of nociceptive signals through binding of opioids to the corresponding opioid receptor. Interfering with the trans-repression effect of downstream regulatory element antagonist modulator (DREAM) on the transcription of the opioid dynorphin-encoding prodynorphin (pdyn) gene might enhance pain relief in the periphery.lld:pubmed
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pubmed-article:18507845pubmed:articleTitleDREAM is reduced in synovial fibroblasts of patients with chronic arthritic pain: is it a suitable target for peripheral pain management?lld:pubmed
pubmed-article:18507845pubmed:affiliationCenter of Experimental Rheumatology, Department of Rheumatology and Institute of Physical Medicine, University Hospital, CH-8091 Zurich, Gloriastrasse 25, Switzerland.lld:pubmed
pubmed-article:18507845pubmed:publicationTypeJournal Articlelld:pubmed
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