The endogenous pain-relieving system depends in part on the regulation of nociceptive signals through binding of opioids to the corresponding opioid receptor. Interfering with the trans-repression effect of downstream regulatory element antagonist modulator (DREAM) on the transcription of the opioid dynorphin-encoding prodynorphin (pdyn) gene might enhance pain relief in the periphery.
Center of Experimental Rheumatology, Department of Rheumatology and Institute of Physical Medicine, University Hospital, CH-8091 Zurich, Gloriastrasse 25, Switzerland.
