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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1991-6-5
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pubmed:abstractText |
The 18F-labeling of 4-borono-D-L-phenylalanine (BPA), a potential target compound for cancer treatment with boron neutron capture therapy, is described. By direct fluorination of BPA with [18F]AcOF or [18F]F2 followed by HPLC separation, 4-borono-2-[18F]fluoro-D,L-phenylalanine was prepared with radiochemical yields of 25-35% and with a radiochemical purity of over 99%. The tissue distribution study showed that the compound has potential as a tracer for pancreas imaging with positron emission tomography. Radiation dosimetry is also described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0883-2889
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
325-8
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pubmed:dateRevised |
2009-6-4
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pubmed:meshHeading |
pubmed-meshheading:1850716-Animals,
pubmed-meshheading:1850716-Boron Compounds,
pubmed-meshheading:1850716-Fluorine Radioisotopes,
pubmed-meshheading:1850716-Isotope Labeling,
pubmed-meshheading:1850716-Male,
pubmed-meshheading:1850716-Mice,
pubmed-meshheading:1850716-Neutrons,
pubmed-meshheading:1850716-Phenylalanine,
pubmed-meshheading:1850716-Radiation-Sensitizing Agents,
pubmed-meshheading:1850716-Radiometry,
pubmed-meshheading:1850716-Tissue Distribution,
pubmed-meshheading:1850716-Tomography, Emission-Computed
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pubmed:year |
1991
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pubmed:articleTitle |
Synthesis and radiation dosimetry of 4-borono-2-[18F]fluoro-D,L-phenylalanine: a target compound for PET and boron neutron capture therapy.
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pubmed:affiliation |
Division of Radiopharmaceutical Chemistry, Tohoku University, Sendai, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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