Source:http://linkedlifedata.com/resource/pubmed/id/18506189
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2008-5-28
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pubmed:abstractText |
Exposure to ionising radiation is an established risk factor for many cancers. We conducted a case-control study to investigate whether exposure to low dose ionisation radiation from diagnostic x-ray procedures could be established as a risk factor for prostate cancer. In all 431 young-onset prostate cancer cases and 409 controls frequency matched by age were included. Exposures to barium meal, barium enema, hip x-rays, leg x-rays and intravenous pyelogram (IVP) were considered. Exposures to barium enema (adjusted odds ratio (OR) 2.06, 95% confidence interval (CI) 1.01-4.20) and hip x-rays (adjusted OR 2.23, 95% CI 1.42-3.49) at least 5 years before diagnosis were significantly associated with increased prostate cancer. For those with a family history of cancer, exposures to hip x-rays dating 10 or 20 years before diagnosis were associated with a significantly increased risk of prostate cancer: adjusted OR 5.01, 95% CI 1.64-15.31 and adjusted OR 14.23, 95% CI 1.83-110.74, respectively. Our findings show that exposure of the prostate gland to diagnostic radiological procedures may be associated with increased cancer risk. This effect seems to be modified by a positive family history of cancer suggesting that genetic factors may play a role in this risk association.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1532-1827
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pubmed:author |
pubmed-author:DearnaleyDD,
pubmed-author:DimitropoulosVV,
pubmed-author:EastonDD,
pubmed-author:EdwardsSS,
pubmed-author:EelesRR,
pubmed-author:EvansSS,
pubmed-author:Gehr-SwainBB,
pubmed-author:GuyMM,
pubmed-author:HallAA,
pubmed-author:KehEE,
pubmed-author:LophatananonAA,
pubmed-author:MuisHH,
pubmed-author:MylesPP,
pubmed-author:O'BrienLL,
pubmed-author:PocockRR,
pubmed-author:WilkinsonRR
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pubmed:issnType |
Electronic
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pubmed:day |
3
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1852-6
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pubmed:dateRevised |
2009-9-11
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pubmed:meshHeading |
pubmed-meshheading:18506189-Case-Control Studies,
pubmed-meshheading:18506189-Dose-Response Relationship, Radiation,
pubmed-meshheading:18506189-Genetic Predisposition to Disease,
pubmed-meshheading:18506189-Humans,
pubmed-meshheading:18506189-Male,
pubmed-meshheading:18506189-Middle Aged,
pubmed-meshheading:18506189-Neoplasms, Radiation-Induced,
pubmed-meshheading:18506189-Prostatic Neoplasms,
pubmed-meshheading:18506189-Radiography,
pubmed-meshheading:18506189-Risk Factors,
pubmed-meshheading:18506189-Urography
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pubmed:year |
2008
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pubmed:articleTitle |
Diagnostic radiation procedures and risk of prostate cancer.
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pubmed:affiliation |
Division of Epidemiology and Public Health, University of Nottingham Medical School, Queens Medical Centre, Nottingham NG7 2UH, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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