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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-6-4
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pubmed:abstractText |
The tumor suppressors p14(ARF) (ARF) and p16(INK4A) (p16) are encoded by overlapping reading frames at the CDKN2A/INK4A locus on chromosome 9p21. In human melanoma, the accumulated evidence has suggested that the predominant tumor suppressor at 9p21 is p16, not ARF. However, recent observations from melanoma-prone families and murine melanoma models suggest a p16-independent tumor suppressor role for ARF. We analyzed a group of melanoma metastases and cell lines to investigate directly whether somatic alterations to the ARF gene support its role as a p16-independent tumor suppressor in human melanoma, assuming that two alterations (genetic and/or epigenetic) would be required to inactivate a gene.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1460-2105
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pubmed:author |
pubmed-author:BastianBoris CBC,
pubmed-author:BusamKlausK,
pubmed-author:FreedbergDaniel EDE,
pubmed-author:GaiWeimingW,
pubmed-author:HoughtonAlanA,
pubmed-author:KaplowMargaritaM,
pubmed-author:Newton-BishopJulia AJA,
pubmed-author:OsmanImanI,
pubmed-author:PolskyDavidD,
pubmed-author:Randerson-MoorJuliette AJA,
pubmed-author:RigasSushila HSH,
pubmed-author:RussakJulieJ,
pubmed-author:Timothy BishopDD,
pubmed-author:TurnerFayeF
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
784-95
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18505964-Animals,
pubmed-meshheading:18505964-Cell Line, Tumor,
pubmed-meshheading:18505964-Chromosomes, Human, Pair 9,
pubmed-meshheading:18505964-DNA Methylation,
pubmed-meshheading:18505964-Gene Deletion,
pubmed-meshheading:18505964-Gene Silencing,
pubmed-meshheading:18505964-Genes, p16,
pubmed-meshheading:18505964-Humans,
pubmed-meshheading:18505964-Immunoblotting,
pubmed-meshheading:18505964-Immunohistochemistry,
pubmed-meshheading:18505964-Melanoma,
pubmed-meshheading:18505964-Melanoma, Experimental,
pubmed-meshheading:18505964-Mice,
pubmed-meshheading:18505964-Microsatellite Repeats,
pubmed-meshheading:18505964-Mutation,
pubmed-meshheading:18505964-Neoplasm Proteins,
pubmed-meshheading:18505964-Polymerase Chain Reaction,
pubmed-meshheading:18505964-Promoter Regions, Genetic,
pubmed-meshheading:18505964-Tumor Suppressor Protein p14ARF
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pubmed:year |
2008
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pubmed:articleTitle |
Frequent p16-independent inactivation of p14ARF in human melanoma.
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pubmed:affiliation |
Department of Dermatology, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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