Linked Life Data

1850593

Source:http://linkedlifedata.com/resource/pubmed/id/1850593

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-5-30
pubmed:abstractText
We studied the effects of psychosocial stress (S) and diazepam (D) on plasma lipids, adrenocorticotropin (ACTH), and corticosterone (B) levels of cockerels fed an atherogenic diet (AD) consisting of 2% cholesterol plus 5% cottonseed oil added to plain mash (PM). Seventy-six eight-week-old DeKalb cockerels were randomly assigned to the following groups: I. PM; II. PM + D; III. PM + S; ;IV. PM + S + D; V. AD; VI. AD + D; VII. AD + S and VIII. AD + S + D. S was induced by housing two birds to a cage and pairing them to a different bird daily. D was administered daily by gavage. Plasma ACTH and B levels were analyzed by RIA. Aortic atherosclerosis was grossly graded on a scale of 0-4 and also by gravimetric planimetry. After 10 weeks: 1. S birds had a significantly higher incidence and severity (p less than 0.04) of aortic atherogenesis and elevated ACTH and B levels (p less than 0.001) compared to unstressed PM groups. 2. AD significantly elevated the plasma levels of cholesterol, triglycerides, and the lipoprotein cholesterol that was precipitated by heparin-manganese (LDL-C + VLDL-C), compared to initial and/or PM levels (p less than 0.001). AD birds had a greater incidence and more severe aortic lesions in comparison to PM groups (p less than 0.002). Plasma hormone levels were significantly lower in birds fed AD alone compared to controls and stressed birds. 3. D significantly reduced the severity of aortic atheroma as well as decreased hormone levels in all treated groups (p less than 0.001). Therefore, we conclude that aortic atherosclerosis in cockerels can be induced by S and/or AD, and D can markedly reduce atherogenesis under these conditions. Since both AD and D decreased plasma ACTH and B levels, the anti-atherogenic action of D in these birds does not seem to directly involve these pituitary-adrenocortical hormones.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0098-6127
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-86
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Effects of diazepam, psychosocial stress and dietary cholesterol on pituitary-adrenocortical hormone levels and experimental atherosclerosis.
pubmed:affiliation
Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't