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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-6-4
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pubmed:databankReference |
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pubmed:abstractText |
The standard therapy for human immunodeficiency virus (HIV)-associated cryptococcal meningitis of amphotericin B (AmB; 0.7 mg/kg per day) plus flucytosine frequently takes >2 weeks to sterilize the cerebral spinal fluid, and acute mortality remains high. A dosage range for AmB of 0.7-1 mg/kg per day is noted in current guidelines, but there are no data comparing 0.7 mg/kg per day with 1 mg/kg per day.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1537-6591
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
123-30
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pubmed:dateRevised |
2008-10-23
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pubmed:meshHeading |
pubmed-meshheading:18505387-AIDS-Related Opportunistic Infections,
pubmed-meshheading:18505387-Adult,
pubmed-meshheading:18505387-Amphotericin B,
pubmed-meshheading:18505387-Anemia,
pubmed-meshheading:18505387-Antifungal Agents,
pubmed-meshheading:18505387-Cerebrospinal Fluid,
pubmed-meshheading:18505387-Creatinine,
pubmed-meshheading:18505387-Cryptococcus neoformans,
pubmed-meshheading:18505387-Female,
pubmed-meshheading:18505387-Flucytosine,
pubmed-meshheading:18505387-Follow-Up Studies,
pubmed-meshheading:18505387-Hemoglobins,
pubmed-meshheading:18505387-Humans,
pubmed-meshheading:18505387-Male,
pubmed-meshheading:18505387-Meningitis, Cryptococcal,
pubmed-meshheading:18505387-Renal Insufficiency,
pubmed-meshheading:18505387-Sex Factors,
pubmed-meshheading:18505387-South Africa,
pubmed-meshheading:18505387-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
High-dose amphotericin B with flucytosine for the treatment of cryptococcal meningitis in HIV-infected patients: a randomized trial.
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pubmed:affiliation |
Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. tihana@never.com
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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