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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-2-2
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pubmed:abstractText |
Sun exposure has been associated with lower death rates for pancreatic cancer in ecological studies. Skin exposure to solar ultraviolet B radiation induces cutaneous production of precursors to 25-hydroxy (OH) vitamin D (D) and is considered the primary contributor to vitamin D status in most populations. Pancreatic islet and duct cells express 25-(OH) D(3)-1alpha-hydroxylase that generates the biologically active 1,25-dihydroxy(OH)(2) D form. Thus, 25(OH)D concentrations could affect pancreatic function and possibly pancreatic cancer etiology. Serum 25-(OH)D is the major circulating vitamin D metabolite and is considered the best indicator of vitamin D status as determined by the sun and diet. Although recent prospective epidemiologic studies of higher predicted vitamin D status score and vitamin D intake and pancreatic cancer risk suggest protective associations, a nested case-control study showed a significant 3-fold increased risk for pancreatic cancer with higher vitamin D status. Limitations of these studies include the former do not measure vitamin D status on pancreatic cancer cases and the later was conducted in a male smoker population. More research is needed, particularly examination of pre-diagnostic vitamin D status and risk of pancreatic cancer, prior to conclusions for vitamin D's potential role in the etiology of this highly fatal cancer.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-10497622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-10609819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-10698482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-10815119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-10901377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-11075718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-11121463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-11158062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-11266389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-11920550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-11978580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-12125099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-12556242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-12711007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-12720576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-12723644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-12837831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-12888824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-12918875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-12974557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-14618623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-14652242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-14742320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-14985208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-15090720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-15168361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-15375018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-15513387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-15551791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-15577289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-15585797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-15644546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-15886696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-15971062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-15992592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-16319673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-16340750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-16352795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-16595770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-16595781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-16958083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-16985031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-17047087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-17096841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-17149699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-17266034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-17327321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-17623801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-17651508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-17971526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-2154330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-2243289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-2963553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-6371345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-8056126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-8613068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-8645577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-9242478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18504144-9376260
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1873-2585
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
89-95
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pubmed:dateRevised |
2011-9-28
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
Vitamin D and pancreatic cancer.
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pubmed:affiliation |
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health Human Services, Rockville, MD, USA. rs221z@nih.gov
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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