Source:http://linkedlifedata.com/resource/pubmed/id/18503008
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2008-10-16
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| pubmed:abstractText |
BACKGROUND: Malnutrition is very prevalent among patients with chronic renal failure. The role of derangements in the gut-brain axis for regulation of appetite in the genesis of anorexia of these patients has not been adequately investigated. Design. Following a randomized, crossover design, we analysed plasma levels of peptide YY (PYY)(1-36) and PYY(3-36) both fasting and after a standardized oral mixed meal or intraperitoneal glucose infusion in 10 stable uraemic patients undergoing peritoneal dialysis and 8 healthy controls, matched for age, gender and body mass index. Main results. Median baseline plasma levels of PYY(1-36) in the different provocation tests oscillated between 406 and 460 pg/mL in patients, as compared with 73 and 100 pg/mL in controls (P < 0.001). Corresponding values for PYY(3-36) oscillated between 235 and 267 pg/mL in patients, versus 56 and 70 pg/mL in controls (P < 0.001). The association of high levels of PYY(3-36) and normal levels of acylated ghrelin (when compared with healthy controls) configurated a markedly pro-anorexigenic pattern in patients. Neither oral intake nor intraperitoneal glucose resulted in significant changes in plasma levels of PYY(1-36) or PYY(3-36) in subjects with renal failure, in contrast with the expected postprandial rise observed in healthy controls (41% for PYY(1-36), P = 0.04 and 32% for PYY(3-36), P = 0.02, median values). CONCLUSIONS: Baseline plasma levels of PYY(1-36) or PYY(3-36) are markedly elevated in patients with renal failure undergoing peritoneal dialysis. Provocation studies disclose a marked disregulation in the postprandial secretion of these anorexigenic peptides, when compared with healthy controls. These findings may contribute to clarify the complex pathogenesis of anorexia of chronic renal failure.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1460-2385
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
23
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3696-703
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:18503008-Adult,
pubmed-meshheading:18503008-Aged,
pubmed-meshheading:18503008-Anorexia,
pubmed-meshheading:18503008-Appetite,
pubmed-meshheading:18503008-Case-Control Studies,
pubmed-meshheading:18503008-Chronic Disease,
pubmed-meshheading:18503008-Cross-Over Studies,
pubmed-meshheading:18503008-Dialysis Solutions,
pubmed-meshheading:18503008-Female,
pubmed-meshheading:18503008-Food, Formulated,
pubmed-meshheading:18503008-Glucose,
pubmed-meshheading:18503008-Humans,
pubmed-meshheading:18503008-Infusions, Parenteral,
pubmed-meshheading:18503008-Male,
pubmed-meshheading:18503008-Malnutrition,
pubmed-meshheading:18503008-Middle Aged,
pubmed-meshheading:18503008-Peptide YY,
pubmed-meshheading:18503008-Peritoneal Dialysis,
pubmed-meshheading:18503008-Renal Insufficiency
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| pubmed:year |
2008
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| pubmed:articleTitle |
Short-term regulation of peptide YY secretion by a mixed meal or peritoneal glucose-based dialysate in patients with chronic renal failure.
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| pubmed:affiliation |
Department of Medicine, University of A Coruña, University Hospital Juan Canalejo, Coruña, Spain. mfontan@canalejo.org
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| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|