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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-10-20
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pubmed:abstractText |
Insulin-like growth factor-binding protein 3 (IGFBP-3) can induce antiproliferative and proapoptotic effects in human cancer cells, by IGF-I independent mechanisms. The antitumor efficacy of recombinant human IGFBP-3 (rhIGFBP-3) and its interaction with chemotherapy in lung and colon cancers, in vitro and in vivo was evaluated. The effects of the different treatments on IGF-IR signaling pathways were also examined.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Dec
|
|
pubmed:issn |
1532-2238
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
487-96
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18502161-Animals,
pubmed-meshheading:18502161-Antineoplastic Agents,
pubmed-meshheading:18502161-Camptothecin,
pubmed-meshheading:18502161-Carboplatin,
pubmed-meshheading:18502161-Cell Line, Tumor,
pubmed-meshheading:18502161-Cell Proliferation,
pubmed-meshheading:18502161-Colonic Neoplasms,
pubmed-meshheading:18502161-Down-Regulation,
pubmed-meshheading:18502161-Drug Synergism,
pubmed-meshheading:18502161-Female,
pubmed-meshheading:18502161-Humans,
pubmed-meshheading:18502161-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:18502161-Insulin-Like Growth Factor Binding Proteins,
pubmed-meshheading:18502161-Lung Neoplasms,
pubmed-meshheading:18502161-MAP Kinase Signaling System,
pubmed-meshheading:18502161-Mice,
pubmed-meshheading:18502161-Mice, Inbred C57BL,
pubmed-meshheading:18502161-Neoplasm Transplantation,
pubmed-meshheading:18502161-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:18502161-Recombinant Proteins,
pubmed-meshheading:18502161-Signal Transduction,
pubmed-meshheading:18502161-Transplantation, Heterologous
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pubmed:year |
2008
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pubmed:articleTitle |
Recombinant human insulin-like growth factor-binding protein 3 inhibits tumor growth and targets the Akt pathway in lung and colon cancer models.
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pubmed:affiliation |
Oncology Department, McGill University, Montreal, QC, Canada. nezha.alami@vmir.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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