Linked Life Data

18502034

Source:http://linkedlifedata.com/resource/pubmed/id/18502034

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-8-22
pubmed:abstractText
This report shows that over-expression of BRMS1 reduces SDF-induced chemotaxis and suppresses nuclear factor-kappaB (NF-kappaB) activity in NSCLC cell line. Inhibition of NF-kappaB activity impairs SDF-1alpha-dependent migration and NF-kappaB can directly bind to the chemokine (C-X-C motif) receptor 4 (CXCR4) promoter invivo. However, knockdown of BRMS1 promotes NSCLC cell migration and CXCR4 expression. Furthermore, BRMS1 and CXCR4 expression levels are inversely correlated in the NSCLC cases. The level of BRMS1 mRNA is found to be markedly lower in the distant metastasis group than in the non-distant metastasis group (P=0.003). However, CXCR4 mRNA was higher in the distant metastasis group than in the non-distant metastasis group (P=0.032). These results indicate that BRMS1 regulates metastatic potential at least in part through the down-regulation of CXCR4, to be indirectly regulated by BRMS1 through nuclear factor-kappaB activation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1872-7980
pubmed:author
pubmed:issnType
Electronic
pubmed:day
28
pubmed:volume
269
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
46-56
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Breast cancer metastasis suppressor 1 inhibits SDF-1alpha-induced migration of non-small cell lung cancer by decreasing CXCR4 expression.
pubmed:affiliation
The Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Medical Science Academy and Sichuan Provincial People's Hospital, Sichuan 610071, PR China. yangjiyun@yeah.net
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't