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rdf:type |
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lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0013018,
umls-concept:C0023467,
umls-concept:C0030705,
umls-concept:C0039194,
umls-concept:C0085732,
umls-concept:C0205263,
umls-concept:C1515895,
umls-concept:C1527169,
umls-concept:C1704243,
umls-concept:C1707455
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pubmed:issue |
11
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pubmed:dateCreated |
2008-7-23
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pubmed:abstractText |
We investigated the usefulness of allogeneic monocyte-derived dendritic cells (allogeneic mDCs) pulsed with leukemic lysates in acute myeloid leukemia (AML). Allogeneic mDCs showed higher expressions of several molecules (HLA-DR, CD80, CD83 or CD86), higher production of IL-12 and higher capacity to stimulate allogeneic T cells compared to both leukemic DCs and autologous mDCs. Autologous T cells primed by allogeneic mDCs displayed a larger number of interferon-gamma-secreting cells against leukemic cells than those primed by either leukemic DCs or autologous mDCs. These results suggest that monocyte-derived DCs from HLA-matched allogeneic donors can be used as an alternative to generate leukemia-specific cytotoxic T cells and to overcome the limitation of leukemic DCs or autologous mDCs.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/CD83 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0145-2126
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1653-60
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pubmed:meshHeading |
pubmed-meshheading:18501426-Antigens, CD,
pubmed-meshheading:18501426-Antigens, CD80,
pubmed-meshheading:18501426-Antigens, CD86,
pubmed-meshheading:18501426-Dendritic Cells,
pubmed-meshheading:18501426-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:18501426-HLA Antigens,
pubmed-meshheading:18501426-HLA-DR Antigens,
pubmed-meshheading:18501426-Histocompatibility,
pubmed-meshheading:18501426-Humans,
pubmed-meshheading:18501426-Immunoglobulins,
pubmed-meshheading:18501426-Interleukin-12,
pubmed-meshheading:18501426-Leukemia, Myeloid, Acute,
pubmed-meshheading:18501426-Leukocytes, Mononuclear,
pubmed-meshheading:18501426-Lymphocyte Activation,
pubmed-meshheading:18501426-Membrane Glycoproteins,
pubmed-meshheading:18501426-Monocytes,
pubmed-meshheading:18501426-Phenotype,
pubmed-meshheading:18501426-T-Lymphocytes,
pubmed-meshheading:18501426-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:18501426-Tissue Donors
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pubmed:year |
2008
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pubmed:articleTitle |
Monocyte-derived dendritic cells from HLA-matched allogeneic donors showed a greater ability to induce leukemic cell-specific T cells in comparison to leukemic cell-derived dendritic cells or monocyte-derived dendritic cells from AML patients.
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pubmed:affiliation |
Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeonnam, South Korea.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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