Linked Life Data

18500912

Source:http://linkedlifedata.com/resource/pubmed/id/18500912

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-5-26
pubmed:abstractText
A nanoscale sensor employing fluorescent resonance energy transfer interactions between fluorescent quantum dots (QDs) and organic quencher molecules can be used for the multiplexed detection of biological antigens in solution. Detection occurs when the antigens to be detected displace quencher-labelled inactivated (or dead) antigens of the same type attached to QD-antibody complexes through equilibrium reactions. This unquenches the QDs, allowing detection to take place through the observation of photoluminescence in solution or through the fluorescence imaging of unquenched QD complexes trapped on filter surfaces. Multiplexing can be accomplished by using several different sizes of QDs, with each size QD labelled with an antibody for a different antigen, providing the ability to detect several types of antigens or biological contaminants simultaneously in near real-time with high specificity and sensitivity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1751-8741
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Fluorescent resonance energy transfer based detection of biological contaminants through hybrid quantum dot-quencher interactions.
pubmed:affiliation
EPIR Technologies Inc., Bolingbrook, IL 60440, USA. rdinakar@epir.com
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.