Source:http://linkedlifedata.com/resource/pubmed/id/18500692
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2008-6-23
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pubmed:abstractText |
Prostate-specific antigen (PSA or KLK3) has been shown to inhibit angiogenesis, but it might also have tumor promoting activities. Thus, it may be possible to modulate prostate cancer growth by stimulating or inhibiting the activity of PSA. To this end we have previously identified peptides that stimulate the activity of PSA. As peptides have several limitations as drug molecules, we screened a chemical library to find drug-like compounds that could be used to modulate the function(s) of PSA.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0270-4137
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pubmed:author | |
pubmed:copyrightInfo |
Copyright (c) 2008 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1143-51
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pubmed:meshHeading |
pubmed-meshheading:18500692-Benzoxazines,
pubmed-meshheading:18500692-Cells, Cultured,
pubmed-meshheading:18500692-Drug Design,
pubmed-meshheading:18500692-Drug Evaluation, Preclinical,
pubmed-meshheading:18500692-Endothelial Cells,
pubmed-meshheading:18500692-Humans,
pubmed-meshheading:18500692-Male,
pubmed-meshheading:18500692-Neovascularization, Physiologic,
pubmed-meshheading:18500692-Prostate-Specific Antigen,
pubmed-meshheading:18500692-Prostatic Neoplasms,
pubmed-meshheading:18500692-Small Molecule Libraries,
pubmed-meshheading:18500692-Structure-Activity Relationship,
pubmed-meshheading:18500692-Umbilical Veins
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pubmed:year |
2008
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pubmed:articleTitle |
Novel small molecule inhibitors for prostate-specific antigen.
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pubmed:affiliation |
Department of Clinical Chemistry, Biomedicum Helsinki, University of Helsinki, Helsinki University Central Hospital, Finland. hannu.k.koistinen@helsinki.fi
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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