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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-6-19
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pubmed:abstractText |
Ets-related gene (ERG), which encodes a member of the Ets family of transcription factors, is a potent oncogene. Chromosomal rearrangements involving ERG are found in acute myeloid leukemia, acute lymphoblastic leukemia, Ewing's sarcoma and more than half of all prostate cancers; however, the normal physiological function of Erg is unknown. We did a sensitized genetic screen of the mouse for regulators of hematopoietic stem cell function and report here a germline mutation of Erg. We show that Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function and the maintenance of normal peripheral blood platelet numbers.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1529-2916
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pubmed:author |
pubmed-author:AlexanderWarren SWS,
pubmed-author:EllisSarahS,
pubmed-author:HackingDouglas FDF,
pubmed-author:HenleyKatya JKJ,
pubmed-author:HiltonDouglas JDJ,
pubmed-author:HylandCraig DCD,
pubmed-author:KileBenjamin TBT,
pubmed-author:KruseElizabeth AEA,
pubmed-author:LoughranStephen JSJ,
pubmed-author:MetcalfDonaldD,
pubmed-author:VossAnne KAK,
pubmed-author:WillsonTracy ATA,
pubmed-author:de GraafCarolyn ACA
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
810-9
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pubmed:meshHeading |
pubmed-meshheading:18500345-Animals,
pubmed-meshheading:18500345-Flow Cytometry,
pubmed-meshheading:18500345-Gene Expression Regulation,
pubmed-meshheading:18500345-Hematopoiesis,
pubmed-meshheading:18500345-Hematopoietic Stem Cells,
pubmed-meshheading:18500345-Humans,
pubmed-meshheading:18500345-Mice,
pubmed-meshheading:18500345-Mice, Mutant Strains,
pubmed-meshheading:18500345-Mutation,
pubmed-meshheading:18500345-Trans-Activators,
pubmed-meshheading:18500345-Transcription, Genetic
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pubmed:year |
2008
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pubmed:articleTitle |
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells.
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pubmed:affiliation |
Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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