| pubmed-article:18499386 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18499386 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:18499386 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:18499386 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:18499386 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
| pubmed-article:18499386 | lifeskim:mentions | umls-concept:C0201734 | lld:lifeskim |
| pubmed-article:18499386 | lifeskim:mentions | umls-concept:C1510438 | lld:lifeskim |
| pubmed-article:18499386 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:18499386 | lifeskim:mentions | umls-concept:C1709630 | lld:lifeskim |
| pubmed-article:18499386 | lifeskim:mentions | umls-concept:C0332324 | lld:lifeskim |
| pubmed-article:18499386 | pubmed:issue | 4-5 | lld:pubmed |
| pubmed-article:18499386 | pubmed:dateCreated | 2008-6-16 | lld:pubmed |
| pubmed-article:18499386 | pubmed:abstractText | A novel method for the quantitation of yonkenafil, a new synthetic phosphodiesterase V inhibitor, in rat plasma using high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) has been developed. The analyte and internal standard (diazepam) were extracted from plasma (100 microl) by liquid-liquid extraction and separated on a C18 column using 10mM ammonium acetate buffer: methanol (15:85, v/v) as mobile phase in a run time of 3.0 min. The detector was a Q-trap mass spectrometer with an ESI interface operating in the multiple reaction monitoring (MRM) mode. The assay was linear over the concentration range 1.0-1000 ng/ml with a limit of detection of 0.20 ng/ml. Intra- and inter-day precision (as relative standard deviation) were both within 8.45% with good accuracy. The method was successfully applied to a preclinical pharmacokinetic study of yonkenafil in rat after sublingual, oral and intravenous administration. The results demonstrate that the sublingual route gives a higher bioavailablity than the oral route and may represent a useful alternative route of yonkenafil administration. | lld:pubmed |
| pubmed-article:18499386 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18499386 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18499386 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18499386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18499386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18499386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18499386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18499386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18499386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18499386 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18499386 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18499386 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18499386 | pubmed:issn | 0731-7085 | lld:pubmed |
| pubmed-article:18499386 | pubmed:author | pubmed-author:WangJiangJ | lld:pubmed |
| pubmed-article:18499386 | pubmed:author | pubmed-author:GuJingkaiJ | lld:pubmed |
| pubmed-article:18499386 | pubmed:author | pubmed-author:KongJianJ | lld:pubmed |
| pubmed-article:18499386 | pubmed:author | pubmed-author:FawcettJ... | lld:pubmed |
| pubmed-article:18499386 | pubmed:author | pubmed-author:YaoJiangJ | lld:pubmed |
| pubmed-article:18499386 | pubmed:author | pubmed-author:WangYingwuY | lld:pubmed |
| pubmed-article:18499386 | pubmed:author | pubmed-author:TangYunbiaoY | lld:pubmed |
| pubmed-article:18499386 | pubmed:author | pubmed-author:TengGuoshengG | lld:pubmed |
| pubmed-article:18499386 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18499386 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:18499386 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:18499386 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18499386 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18499386 | pubmed:pagination | 985-9 | lld:pubmed |
| pubmed-article:18499386 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:18499386 | pubmed:meshHeading | pubmed-meshheading:18499386... | lld:pubmed |
| pubmed-article:18499386 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18499386 | pubmed:articleTitle | A rapid and sensitive LC-MS/MS assay to quantify yonkenafil in rat plasma with application to preclinical pharmacokinetics studies. | lld:pubmed |
| pubmed-article:18499386 | pubmed:affiliation | Research Center for Drug Metabolism, College of Life Science, Jilin University, Changchun 130023, China. | lld:pubmed |
| pubmed-article:18499386 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18499386 | pubmed:publicationType | Evaluation Studies | lld:pubmed |
