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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
1991-5-22
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pubmed:abstractText |
Catecholamines are involved critically in the mechanisms of liver cell proliferation by acting on hepatic alpha-1 and beta-2 adrenoceptors. To identify the role of these receptors in human hepatocellular carcinoma (HCC), the density was examined of alpha-1 and beta-2 adrenoceptors with their affinity and coupling of beta-2 adrenoceptors to adenylate cyclase in HCC tissue and in nonadjacent/nontumor tissue from the same livers. Studies were also done on healthy livers from age-matched and sex-matched patients undergoing abdominal surgery for nonhepatic diseases. Twenty-two HCC had a decrease of about 72% in alpha-1 adrenoceptor density compared with their nonadjacent/nontumor tissue and a decrease of about 40% compared with healthy controls. Nonadjacent/nontumor tissue from HCC patients had a 125% increase in alpha-1 adrenoceptor density compared with healthy livers. Twenty-three of 24 HCC had an increase of about 180% in beta adrenoceptor density compared with their nonadjacent/nontumor tissue and healthy controls. Beta adrenoceptors were coupled to adenylate cyclase, as evidenced by a guanosine triphosphate-mediated right shift in (-)-isoproterenol competition isotherms and by cyclic adenosine monophosphate (cAMP) production after stimulation with (-)-isoproterenol. The HCC tissue yielded a larger increase in cAMP than nonadjacent/nontumor tissue and healthy controls. The authors conclude that a higher density of alpha-1 adrenoceptors in nonadjacent/nontumor tissue from HCC characterizes the "healthy" part of the liver in HCC patients and that an increase in beta-2 and a decrease in alpha-1 adrenoceptor densities characterize the tumor part of the liver in human HCC.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0008-543X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2543-51
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1849789-Adenylate Cyclase,
pubmed-meshheading:1849789-Aged,
pubmed-meshheading:1849789-Binding, Competitive,
pubmed-meshheading:1849789-Carcinoma, Hepatocellular,
pubmed-meshheading:1849789-Child, Preschool,
pubmed-meshheading:1849789-Female,
pubmed-meshheading:1849789-Humans,
pubmed-meshheading:1849789-Liver Neoplasms,
pubmed-meshheading:1849789-Male,
pubmed-meshheading:1849789-Middle Aged,
pubmed-meshheading:1849789-Receptors, Adrenergic, alpha,
pubmed-meshheading:1849789-Receptors, Adrenergic, beta
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pubmed:year |
1991
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pubmed:articleTitle |
Changes in alpha-1 and beta-2 adrenoceptor density in human hepatocellular carcinoma.
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pubmed:affiliation |
Servizio di Endocrinologia, Ospedale L. Sacco Vialba, Milano, Italy.
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pubmed:publicationType |
Journal Article
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