| pubmed-article:18497693 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18497693 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:18497693 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:18497693 | lifeskim:mentions | umls-concept:C0290928 | lld:lifeskim |
| pubmed-article:18497693 | lifeskim:mentions | umls-concept:C0920569 | lld:lifeskim |
| pubmed-article:18497693 | lifeskim:mentions | umls-concept:C1705165 | lld:lifeskim |
| pubmed-article:18497693 | lifeskim:mentions | umls-concept:C0031164 | lld:lifeskim |
| pubmed-article:18497693 | lifeskim:mentions | umls-concept:C0035124 | lld:lifeskim |
| pubmed-article:18497693 | lifeskim:mentions | umls-concept:C2700061 | lld:lifeskim |
| pubmed-article:18497693 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:18497693 | pubmed:dateCreated | 2008-5-23 | lld:pubmed |
| pubmed-article:18497693 | pubmed:abstractText | The mitochondrial permeability transition (MPT) mediates hepatic necrosis after ischemia and reperfusion (I/R). Here, we studied the role of c-Jun N-terminal kinase 2 (JNK2) in MPT-induced liver injury. Wildtype (WT) and JNK2 knockout (KO) mice underwent 70% liver ischemia for 1 hr followed by reperfusion for 8 hr, after which hepatocyte injury and animal survival was assessed. Compared with WT, JNK2 KO mice had 38% less alanine transaminase release and 39% less necrosis by histology. Survival out to 14 days was also greater in JNK2 KO mice (57% vs. 11%), and overall Kaplan-Meier survival was improved. No difference in apoptosis was observed. Intravital multiphoton microscopy of potential-indicating rhodamine 123 after reperfusion revealed depolarized mitochondria in 82% of WT hepatocytes, which decreased to 43% in JNK2 KO hepatocytes. In conclusion, JNK2 contributes to hepatocellular injury and death after I/R in association with increased mitochondrial dysfunction via the MPT. | lld:pubmed |
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| pubmed-article:18497693 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18497693 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18497693 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18497693 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18497693 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18497693 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18497693 | pubmed:month | May | lld:pubmed |
| pubmed-article:18497693 | pubmed:issn | 0041-1337 | lld:pubmed |
| pubmed-article:18497693 | pubmed:author | pubmed-author:LemastersJohn... | lld:pubmed |
| pubmed-article:18497693 | pubmed:author | pubmed-author:ZhongZhiZ | lld:pubmed |
| pubmed-article:18497693 | pubmed:author | pubmed-author:TheruvathTom... | lld:pubmed |
| pubmed-article:18497693 | pubmed:author | pubmed-author:SnoddyMark... | lld:pubmed |
| pubmed-article:18497693 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18497693 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:18497693 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:18497693 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18497693 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18497693 | pubmed:pagination | 1500-4 | lld:pubmed |
| pubmed-article:18497693 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:18497693 | pubmed:meshHeading | pubmed-meshheading:18497693... | lld:pubmed |
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| pubmed-article:18497693 | pubmed:meshHeading | pubmed-meshheading:18497693... | lld:pubmed |
| pubmed-article:18497693 | pubmed:meshHeading | pubmed-meshheading:18497693... | lld:pubmed |
| pubmed-article:18497693 | pubmed:meshHeading | pubmed-meshheading:18497693... | lld:pubmed |
| pubmed-article:18497693 | pubmed:meshHeading | pubmed-meshheading:18497693... | lld:pubmed |
| pubmed-article:18497693 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18497693 | pubmed:articleTitle | Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun N-terminal kinase 2. | lld:pubmed |
| pubmed-article:18497693 | pubmed:affiliation | Center for Cell Death, Injury and Regeneration, Department of Pharmaceutical and Biomedical Sciences, Charleston, SC, USA. | lld:pubmed |
| pubmed-article:18497693 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18497693 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18497693 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:26420 | entrezgene:pubmed | pubmed-article:18497693 | lld:entrezgene |
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