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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-5-23
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pubmed:abstractText |
The mitochondrial permeability transition (MPT) mediates hepatic necrosis after ischemia and reperfusion (I/R). Here, we studied the role of c-Jun N-terminal kinase 2 (JNK2) in MPT-induced liver injury. Wildtype (WT) and JNK2 knockout (KO) mice underwent 70% liver ischemia for 1 hr followed by reperfusion for 8 hr, after which hepatocyte injury and animal survival was assessed. Compared with WT, JNK2 KO mice had 38% less alanine transaminase release and 39% less necrosis by histology. Survival out to 14 days was also greater in JNK2 KO mice (57% vs. 11%), and overall Kaplan-Meier survival was improved. No difference in apoptosis was observed. Intravital multiphoton microscopy of potential-indicating rhodamine 123 after reperfusion revealed depolarized mitochondria in 82% of WT hepatocytes, which decreased to 43% in JNK2 KO hepatocytes. In conclusion, JNK2 contributes to hepatocellular injury and death after I/R in association with increased mitochondrial dysfunction via the MPT.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-10766806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-10989667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-12065751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-12223356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-12447876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-12557154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-12692185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-12729580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-14517806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-15316358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-15486922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-15698843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-15885356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-16571730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-16831600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-16937364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-16979204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-17175270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-18023036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-18028319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-7778168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-9774651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18497693-9925795
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1500-4
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:18497693-Animals,
pubmed-meshheading:18497693-Apoptosis,
pubmed-meshheading:18497693-Intracellular Membranes,
pubmed-meshheading:18497693-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:18497693-Mice,
pubmed-meshheading:18497693-Mice, Knockout,
pubmed-meshheading:18497693-Mitochondria, Liver,
pubmed-meshheading:18497693-Mitochondrial Membranes,
pubmed-meshheading:18497693-Mitogen-Activated Protein Kinase 9,
pubmed-meshheading:18497693-Permeability,
pubmed-meshheading:18497693-Reperfusion Injury
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pubmed:year |
2008
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pubmed:articleTitle |
Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun N-terminal kinase 2.
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pubmed:affiliation |
Center for Cell Death, Injury and Regeneration, Department of Pharmaceutical and Biomedical Sciences, Charleston, SC, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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