Linked Life Data

18497671

Source:http://linkedlifedata.com/resource/pubmed/id/18497671

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2008-5-23
pubmed:abstractText
Mast cells are best known as primary responders in allergic reactions, including anaphylaxis and asthma. However, recent studies have shown that mast cells are functionally diverse cells with immunoregulatory properties that influence both the innate and adaptive immunities. Mast cells are capable of producing an array of both proinflammatory and anti-inflammatory mediators, acting as antigen-presenting cells, and expressing a spectrum of costimulatory molecules. Moreover, mast cells seem to confer a certain degree of immune privilege to tissues in concert with T-regulatory cells and are essential players in fibrotic conditions. The following review of the literature serves to further define the role of mast cells in the immunologic reactions affecting transplanted solid organ grafts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0041-1337
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1365-71
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The role of mast cells after solid organ transplantation.
pubmed:affiliation
Michael E DeBakey Department of Surgery, Division of Transplant and Assist Devices, Baylor College of Medicine, Houston, TX 77030, USA. jahanyar@bcm.tmc.edu
pubmed:publicationType
Journal Article, Review