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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Pt 2
|
| pubmed:dateCreated |
1991-5-9
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| pubmed:abstractText |
Cortical collecting ducts (CCD) from inbred Dahl salt-sensitive rats were perfused in vitro to study effects of arginine vasopressin (AVP, present in the bath) and deoxycorticosterone pivalate (DOC) pretreatment on lumen-to-bath and bath-to-lumen fluxes of 22Na+ (J1----b and Jb----1 in pmol.min-1.mm-1, respectively), hydraulic conductivity (Pf, microns/s), and transepithelial voltage (VT, mV). J1----b was 37.1 +/- 5.3 (mean +/- SE) in untreated rats and increased to 83.2 +/- 15.9 with AVP. VT increased from -0.3 +/- 0.6 to -7.0 +/- 2.0. In DOC-pretreated rat CCDs, baseline J1----b was higher (85.1 +/- 7.6) as was VT (-11.3 +/- 1.7); J1b----b and VT were doubled with AVP addition (185.6 +/- 18.6 and -21.7 +/- 2.3, respectively). Thus J1----b in AVP-stimulated CCDs from untreated rats was not significantly different from control (no AVP) J1----b from DOC-pretreated rats; however, AVP produced a greater J1----b increase in the latter CCDs. Neither AVP nor DOC had an effect on Jb----1, which ranged from 25 to 50. Benzamil reduced J1----b to values not significantly different from Jb----1, and VT became zero in CCDs treated with both AVP and DOC, indicating Na+ transport stimulated by both hormones occurs through apical membrane Na+ channels. Pf increased from 59 +/- 80 to 1,072 +/- 176 with AVP addition to untreated rat CCDs and was unaltered by DOC or benzamil. Thus the Dahl rat CCD exhibits a transport response to AVP and DOC that is indistinguishable from that observed in Sprague-Dawley rats, as previously reported by this laboratory.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amiloride,
http://linkedlifedata.com/resource/pubmed/chemical/Arginine Vasopressin,
http://linkedlifedata.com/resource/pubmed/chemical/Desoxycorticosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium, Dietary,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/benzamil
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0002-9513
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
260
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
F471-8
|
| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:1849360-Absorption,
pubmed-meshheading:1849360-Amiloride,
pubmed-meshheading:1849360-Animals,
pubmed-meshheading:1849360-Arginine Vasopressin,
pubmed-meshheading:1849360-Body Water,
pubmed-meshheading:1849360-Cell Membrane,
pubmed-meshheading:1849360-Desoxycorticosterone,
pubmed-meshheading:1849360-Drug Synergism,
pubmed-meshheading:1849360-Hypertension,
pubmed-meshheading:1849360-Kidney Tubules, Collecting,
pubmed-meshheading:1849360-Kinetics,
pubmed-meshheading:1849360-Male,
pubmed-meshheading:1849360-Osmolar Concentration,
pubmed-meshheading:1849360-Rats,
pubmed-meshheading:1849360-Rats, Inbred Strains,
pubmed-meshheading:1849360-Sodium,
pubmed-meshheading:1849360-Sodium, Dietary,
pubmed-meshheading:1849360-Sodium Channels
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| pubmed:year |
1991
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| pubmed:articleTitle |
Effects of AVP and deoxycorticosterone on Na+ and water transport in the Dahl salt-sensitive rat CCD.
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| pubmed:affiliation |
Department of Physiology, University of Alabama 35294.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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