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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-7-14
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pubmed:abstractText |
Substance P (SP) and chemokines play critical roles in acute pancreatitis. SP elevates cytosolic calcium in pancreatic acinar cells and elevated cytosolic calcium is thought to be an early event in the pathogenesis of acute pancreatitis. SP induces production of chemokines MCP-1, MIP-1alpha and MIP-2 in pancreatic acinar cells, however the exact mechanism by which SP stimulates the production of these pro-inflammatory mediators remain undetermined. The aim of the present study is to investigate the role of calcium in SP-induced chemokine production in pancreatic acinar cells and to establish the signal transduction mechanisms involved.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-10494840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-10669417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-10934033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-11435443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-11741951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-11751160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-12684214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-1378274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-1379366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-1472005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-14730005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-15265887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-15629143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-16575915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-16873893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-16873895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-1700106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-18205703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-2147038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-2244923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-2338654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-2445214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-3113491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-7511591,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18493246-9810275
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
154
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1339-48
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18493246-Animals,
pubmed-meshheading:18493246-Blotting, Western,
pubmed-meshheading:18493246-Calcium,
pubmed-meshheading:18493246-Cell Nucleus,
pubmed-meshheading:18493246-Cell Survival,
pubmed-meshheading:18493246-Chemokines,
pubmed-meshheading:18493246-Cytosol,
pubmed-meshheading:18493246-DNA,
pubmed-meshheading:18493246-Enzyme Activation,
pubmed-meshheading:18493246-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:18493246-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:18493246-Male,
pubmed-meshheading:18493246-Mice,
pubmed-meshheading:18493246-NF-kappa B,
pubmed-meshheading:18493246-Pancreas,
pubmed-meshheading:18493246-Phosphorylation,
pubmed-meshheading:18493246-Protein Kinase C,
pubmed-meshheading:18493246-Signal Transduction,
pubmed-meshheading:18493246-Substance P,
pubmed-meshheading:18493246-Transcription Factor AP-1,
pubmed-meshheading:18493246-Type C Phospholipases
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pubmed:year |
2008
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pubmed:articleTitle |
Role of calcium in substance P-induced chemokine synthesis in mouse pancreatic acinar cells.
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pubmed:affiliation |
Department of Pharmacology, National University of Singapore, Singapore.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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