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pubmed:abstractText |
The combination of gene expression profiling with linkage analysis has become a powerful paradigm for mapping gene expression quantitative trait loci (eQTL). To date, most studies have searched for eQTL by analyzing gene expression traits one at a time. As thousands of expression traits are typically analyzed, this can reduce power because of the need to correct for the number of hypothesis tests performed. In addition, gene expression traits exhibit a complex correlation structure, which is ignored when analyzing traits individually.
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pubmed:affiliation |
Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA. sbiswas@u.washington.edu
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