Linked Life Data

18491049

Source:http://linkedlifedata.com/resource/pubmed/id/18491049

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
186
pubmed:dateCreated
2008-5-20
pubmed:abstractText
There is increasing awareness that processes, such as development, aging and cancer, are governed, to a considerable extent, by epigenetic processes, such as DNA and histone modifications. The sites of these modifications in turn reflect their position and role in the nuclear architecture. Since epigenetic changes are easier to reverse than mutations, drugs that remove or add the chemical tags are at the forefront of research for the treatment of cancerous and inflammatory diseases. This review will use selected examples to develop a unified view that might assist the systematic development of novel therapeutic regimens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0171-2004
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-103
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Scaffold/matrix attachment regions (S/MARs): relevance for disease and therapy.
pubmed:affiliation
Helmholtz-Zentrum für Infektionsforschung MBIO/Epigenetic Regulation, Inhoffenstrasse 7, Braunschweig, Germany.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't