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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-5-20
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pubmed:abstractText |
Listeria monocytogenes escapes from the phagosome of macrophages and replicates within the cytosolic compartment. The macrophage responds to L. monocytogenes through detection pathways located on the cell surface (TLRs) and within the cytosol (Nod-like receptors) to promote inflammatory processes aimed at clearing the pathogen. Cytosolic L. monocytogenes activates caspase 1, resulting in post-translational processing of the cytokines IL-1beta and IL-18 as well as caspase 1-dependent cell death (pyroptosis). We demonstrate that the presence of L. monocytogenes within the cytosolic compartment induces caspase 1 activation through multiple Nod-like receptors, including Ipaf and Nalp3. Flagellin expression by cytosolic L. monocytogenes was detected through Ipaf in a dose-dependent manner. Concordantly, detection of flagellin promoted bacterial clearance in a murine infection model. Finally, we provide evidence that suggests cytosolic L. monocytogenes activates caspase 1 through a third pathway, which signals through the adaptor protein ASC. Thus, L. monocytogenes activates caspase 1 in macrophages via multiple pathways, all of which detect the presence of bacteria within the cytosol.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/56005710,
http://linkedlifedata.com/resource/pubmed/grant/AI025032,
http://linkedlifedata.com/resource/pubmed/grant/AI032972,
http://linkedlifedata.com/resource/pubmed/grant/AI052286,
http://linkedlifedata.com/resource/pubmed/grant/AI065878,
http://linkedlifedata.com/resource/pubmed/grant/K08 AI065878-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI025032-24,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI032972-15,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI032972-20,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI052286-10,
http://linkedlifedata.com/resource/pubmed/grant/R37 AI025032-19,
http://linkedlifedata.com/resource/pubmed/grant/T32CA009537
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CIAS1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Flagellin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/Ipaf protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Pycard protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7558-64
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pubmed:dateRevised |
2011-3-15
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pubmed:meshHeading |
pubmed-meshheading:18490757-Animals,
pubmed-meshheading:18490757-Apoptosis Regulatory Proteins,
pubmed-meshheading:18490757-Calcium-Binding Proteins,
pubmed-meshheading:18490757-Carrier Proteins,
pubmed-meshheading:18490757-Caspase 1,
pubmed-meshheading:18490757-Cytoskeletal Proteins,
pubmed-meshheading:18490757-Cytosol,
pubmed-meshheading:18490757-Enzyme Activation,
pubmed-meshheading:18490757-Flagellin,
pubmed-meshheading:18490757-Interleukin-18,
pubmed-meshheading:18490757-Interleukin-1beta,
pubmed-meshheading:18490757-Listeria monocytogenes,
pubmed-meshheading:18490757-Listeriosis,
pubmed-meshheading:18490757-Macrophages,
pubmed-meshheading:18490757-Mice,
pubmed-meshheading:18490757-Mice, Inbred C57BL,
pubmed-meshheading:18490757-Mice, Mutant Strains,
pubmed-meshheading:18490757-Phagosomes,
pubmed-meshheading:18490757-Toll-Like Receptors
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pubmed:year |
2008
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pubmed:articleTitle |
Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection.
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pubmed:affiliation |
Department of Immunology, University of Washington, Seattle WA 98195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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