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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2008-5-28
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pubmed:abstractText |
Opening of the mitochondrial permeability transition pore (mPTP) is a crucial event in lethal reperfusion injury. Phosphorylation (inhibition) of glycogen synthase kinase-3beta (GSK3beta) has been involved in cardioprotection. We investigated whether phosphorylated GSK3beta may protect the heart via the inhibition of mPTP opening during postconditioning.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2761-8
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:18490522-Animals,
pubmed-meshheading:18490522-Cyclosporine,
pubmed-meshheading:18490522-Disease Models, Animal,
pubmed-meshheading:18490522-Enzyme Inhibitors,
pubmed-meshheading:18490522-Glycogen Synthase Kinase 3,
pubmed-meshheading:18490522-Indoles,
pubmed-meshheading:18490522-Ischemic Preconditioning, Myocardial,
pubmed-meshheading:18490522-Maleimides,
pubmed-meshheading:18490522-Mice,
pubmed-meshheading:18490522-Mice, Inbred C57BL,
pubmed-meshheading:18490522-Mice, Transgenic,
pubmed-meshheading:18490522-Microscopy, Electron,
pubmed-meshheading:18490522-Mitochondria,
pubmed-meshheading:18490522-Mitochondrial Membrane Transport Proteins,
pubmed-meshheading:18490522-Myocardial Infarction,
pubmed-meshheading:18490522-Myocardial Reperfusion Injury,
pubmed-meshheading:18490522-Myocytes, Cardiac,
pubmed-meshheading:18490522-Oxidative Phosphorylation,
pubmed-meshheading:18490522-Phosphorylation
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pubmed:year |
2008
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pubmed:articleTitle |
Inhibition of GSK3beta by postconditioning is required to prevent opening of the mitochondrial permeability transition pore during reperfusion.
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pubmed:affiliation |
INSERM U886, Université Claude Bernard Lyon, 69373 Lyon, France. ovize@sante.univ-lyon1.fr.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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