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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-6-6
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pubmed:abstractText |
The incidence of breast cancer has doubled over the past 20 years in the Czech Republic. Hereditary factors may be a cause of young onset, bilateral breast or ovarian cancer, and familial accumulation of the disease. BRCA1 and BRCA2 mutations account for an important fraction of hereditary breast and ovarian cancer cases. One thousand and ten unrelated high-risk probands with breast and/or ovarian cancer were analysed for the presence of a BRCA1 or BRCA2 gene mutation at the Masaryk Memorial Cancer Institute (Czech Republic) during 1999-2006.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-10090482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-10570174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-10788334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-11292340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-11320250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-11526114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-11802209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-12635174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-12677558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-12759930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-15026808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-15829246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-16283147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-16792514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-17561994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-7666770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-7825587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-7894493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-8896551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-9180865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-9278062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-9450896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-9497246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18489799-9805131
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
140
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18489799-Age of Onset,
pubmed-meshheading:18489799-BRCA1 Protein,
pubmed-meshheading:18489799-BRCA2 Protein,
pubmed-meshheading:18489799-Breast Neoplasms,
pubmed-meshheading:18489799-Breast Neoplasms, Male,
pubmed-meshheading:18489799-Czech Republic,
pubmed-meshheading:18489799-DNA Mutational Analysis,
pubmed-meshheading:18489799-Female,
pubmed-meshheading:18489799-Genetic Predisposition to Disease,
pubmed-meshheading:18489799-Humans,
pubmed-meshheading:18489799-Male,
pubmed-meshheading:18489799-Mutation,
pubmed-meshheading:18489799-Ovarian Neoplasms,
pubmed-meshheading:18489799-Risk Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Spectrum and characterisation of BRCA1 and BRCA2 deleterious mutations in high-risk Czech patients with breast and/or ovarian cancer.
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pubmed:affiliation |
Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic. emachack@mou.cz
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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