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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-5-20
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pubmed:abstractText |
Activated protein C (APC) regulates thrombin generation and inhibits apoptosis. Endothelial protein C receptor (EPCR)-bound protein C is activated by thrombomodulin-bound thrombin. APC inactivates coagulation factors (F)Va/VIIIa and generates cytoprotective signaling downstream of protease-activated receptor-1 (PAR-1). Binding of APC to EPCR both modifies and induces PAR-1 signaling, but it is unknown if protein C interacts with cells in an alternative manner.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1538-7836
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
995-1002
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18489431-Blood Platelets,
pubmed-meshheading:18489431-Calcium,
pubmed-meshheading:18489431-Cell Adhesion,
pubmed-meshheading:18489431-Dose-Response Relationship, Drug,
pubmed-meshheading:18489431-Gene Expression Regulation,
pubmed-meshheading:18489431-Humans,
pubmed-meshheading:18489431-Kinetics,
pubmed-meshheading:18489431-LDL-Receptor Related Proteins,
pubmed-meshheading:18489431-Models, Biological,
pubmed-meshheading:18489431-Platelet Adhesiveness,
pubmed-meshheading:18489431-Platelet Glycoprotein GPIb-IX Complex,
pubmed-meshheading:18489431-Protein C,
pubmed-meshheading:18489431-Receptors, LDL,
pubmed-meshheading:18489431-Receptors, Lipoprotein,
pubmed-meshheading:18489431-Signal Transduction
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pubmed:year |
2008
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pubmed:articleTitle |
Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2.
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pubmed:affiliation |
Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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