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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1991-4-30
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pubmed:abstractText |
We conducted a retrospective study in 229 patients to determine the prevalence of hepatitis C virus (HCV) according to the type of liver disease and also the serum hepatitis B virus (HBV) status. There were 55 cases of hepatocellular carcinoma (HCC), 78 cases of alcoholic cirrhosis (AC) and 96 cases of non-cirrhotic alcohol liver disease (NCA). Half the AC and NCA groups were constituted of patients with or without serum HBV markers. The prevalence of anti-HCV antibodies in HCC (58.2%) was significantly higher than in the other groups (AC, 35.9%; NCA, 17.7%). Combining the two AC and NCA groups gave a 25.8% anti-HCV prevalence in the alcoholics. Altogether anti-HCV antibodies were more frequently present in HBV-positive than in HBV-negative patients (42.2 vs. 26.1%, p less than 0.01), although the difference was not significant when the HCC group was separately analysed. The S/N ratio of anti-HCV-positive samples varied according to the type of the disease (tumorous vs. non-tumorous) and to the serum HBV status. Indeed, 65.6% of HCC had a S/N greater than 4 compared to only 32.2 and 23.5% in AC and NCA, respectively (p less than 0.01). On the other hand more than half of the AC and NCA had a S/N less than 2, indicating possible artefacts in certain cases. The 15 HBsAg and anti-HCV-positive patients had a significantly lower mean S/N than patients displaying only antibodies against HBV, even in the HCC group.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0168-8278
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
70-4
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1848875-Aged,
pubmed-meshheading:1848875-Carcinoma, Hepatocellular,
pubmed-meshheading:1848875-Female,
pubmed-meshheading:1848875-France,
pubmed-meshheading:1848875-Hepatitis Antibodies,
pubmed-meshheading:1848875-Hepatitis B,
pubmed-meshheading:1848875-Hepatitis B Surface Antigens,
pubmed-meshheading:1848875-Hepatitis C,
pubmed-meshheading:1848875-Humans,
pubmed-meshheading:1848875-Liver,
pubmed-meshheading:1848875-Liver Cirrhosis, Alcoholic,
pubmed-meshheading:1848875-Liver Neoplasms,
pubmed-meshheading:1848875-Male,
pubmed-meshheading:1848875-Middle Aged,
pubmed-meshheading:1848875-Prevalence,
pubmed-meshheading:1848875-Retrospective Studies
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pubmed:year |
1991
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pubmed:articleTitle |
Association between HCV and HBV infection in hepatocellular carcinoma and alcoholic liver disease.
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pubmed:affiliation |
Liver Unit, Hospital Laënnec, Paris, France.
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pubmed:publicationType |
Journal Article
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