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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-5-28
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pubmed:abstractText |
T-type Ca2+ channels (T channels) underlie rhythmic burst discharges during neuronal oscillations that are typical during sleep. However, the Ca2+-dependent effectors that are selectively regulated by T currents remain unknown. We found that, in dendrites of nucleus reticularis thalami (nRt), intracellular Ca2+ concentration increases were dominated by Ca2+ influx through T channels and shaped rhythmic bursting via competition between Ca2+-dependent small-conductance (SK)-type K+ channels and Ca2+ uptake pumps. Oscillatory bursting was initiated via selective activation of dendritically located SK2 channels, whereas Ca2+ sequestration by sarco/endoplasmic reticulum Ca2+-ATPases (SERCAs) and cumulative T channel inactivation dampened oscillations. Sk2-/- (also known as Kcnn2) mice lacked cellular oscillations, showed a greater than threefold reduction in low-frequency rhythms in the electroencephalogram of non-rapid-eye-movement sleep and had disrupted sleep. Thus, the interplay of T channels, SK2 channels and SERCAs in nRt dendrites comprises a specialized Ca2+ signaling triad to regulate oscillatory dynamics related to sleep.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Local,
http://linkedlifedata.com/resource/pubmed/chemical/Apamin,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Kcnn1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Kcnn2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Mibefradil,
http://linkedlifedata.com/resource/pubmed/chemical/Sarcoplasmic Reticulum...,
http://linkedlifedata.com/resource/pubmed/chemical/Small-Conductance...,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/cyclopiazonic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1097-6256
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
683-92
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pubmed:meshHeading |
pubmed-meshheading:18488023-Anesthetics, Local,
pubmed-meshheading:18488023-Animals,
pubmed-meshheading:18488023-Animals, Newborn,
pubmed-meshheading:18488023-Apamin,
pubmed-meshheading:18488023-Biological Clocks,
pubmed-meshheading:18488023-Calcium,
pubmed-meshheading:18488023-Calcium Channel Blockers,
pubmed-meshheading:18488023-Dendrites,
pubmed-meshheading:18488023-Electric Stimulation,
pubmed-meshheading:18488023-Electroencephalography,
pubmed-meshheading:18488023-Enzyme Inhibitors,
pubmed-meshheading:18488023-Female,
pubmed-meshheading:18488023-Indoles,
pubmed-meshheading:18488023-Membrane Potentials,
pubmed-meshheading:18488023-Mibefradil,
pubmed-meshheading:18488023-Mice,
pubmed-meshheading:18488023-Mice, Knockout,
pubmed-meshheading:18488023-Midline Thalamic Nuclei,
pubmed-meshheading:18488023-Neurons,
pubmed-meshheading:18488023-Patch-Clamp Techniques,
pubmed-meshheading:18488023-Sarcoplasmic Reticulum Calcium-Transporting ATPases,
pubmed-meshheading:18488023-Sleep,
pubmed-meshheading:18488023-Small-Conductance Calcium-Activated Potassium Channels,
pubmed-meshheading:18488023-Tetrodotoxin,
pubmed-meshheading:18488023-Walking
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pubmed:year |
2008
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pubmed:articleTitle |
T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites.
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pubmed:affiliation |
Division of Pharmacology and Neurobiology, Biozentrum, University of Basel, Klingelbergstr. 70, CH-4056 Basel, Switzerland.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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