Linked Life Data

18487851

Source:http://linkedlifedata.com/resource/pubmed/id/18487851

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-5-19
pubmed:abstractText
Alzheimer's disease (AD) affects approximately 4.5 million people in the U.S. and this number will increase as the population ages and the life-span increases. Therefore, of paramount importance is identifying mechanisms and factors that affect the risk of developing AD. The etiology and pathogenic mechanisms for AD have not been defined, although inflammation within the brain is thought to play a role. Consistent with this hypothesis, studies suggest that peripheral infections contribute to the inflammatory state of the central nervous system. Periodontitis is a prevalent, persistent peripheral infection associated with gram negative, anaerobic bacteria that are capable of exhibiting localized and systemic infections in the host. This review offers a hypothetical link between periodontitis and AD and will present possible mechanistic links between periodontitis related inflammation and AD. It will review the pathogenesis of periodontitis and the mechanisms by which periodontal infections may affect the onset and progression of AD. Since periodontitis is a treatable condition, it may be a readily modifiable risk factor for AD.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1387-2877
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
437-49
pubmed:dateRevised
2011-6-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Alzheimer's disease and peripheral infections: the possible contribution from periodontal infections, model and hypothesis.
pubmed:affiliation
Department of Periodontics and Implant Dentistry and Basic Sciences, NYU College of Dentistry, New York, NY 10010, USA. ark5@nyu.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't