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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-4-25
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pubmed:abstractText |
The only peptide of Sendai virus that is recognized by cytotoxic T lymphocytes (CTL) in B6 mice was found with (i) the use of recombinant vaccinia virus constructs containing separate genes of Sendai virus and (ii) a set of overlapping peptides completely spanning the identified nucleoprotein (NP) gene product. This immunodominant NP peptide is recognized by Sendai virus-specific CTL that are known to have therapeutic effects in vivo. By subcutaneous immunization, this peptide induced Sendai virus and NP peptide-specific CTL memory responses in vivo. Most importantly, mice that had been immunized with this peptide were protected against a lethal virus dose, indicating that viral peptides can be used as antiviral T-cell vaccines. The induction of T-cell memory by free peptide immunization potentially has wide applicability in biology and medicine, including protection against infectious disease.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-1130679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-1692084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-2168920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-2199065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-2420472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-2443447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-2465904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-2536110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-2542021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-2555063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-2578661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-2586628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-3018121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-3052209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-6092688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-6185570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-6204335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-6206190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-6267157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-6311565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-6316257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-6332201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1848698-6601180
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2283-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1848698-Animals,
pubmed-meshheading:1848698-Cells, Cultured,
pubmed-meshheading:1848698-Clone Cells,
pubmed-meshheading:1848698-Cytotoxicity, Immunologic,
pubmed-meshheading:1848698-Mice,
pubmed-meshheading:1848698-Mice, Inbred Strains,
pubmed-meshheading:1848698-Parainfluenza Virus 1, Human,
pubmed-meshheading:1848698-Paramyxoviridae Infections,
pubmed-meshheading:1848698-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:1848698-Vaccines, Synthetic,
pubmed-meshheading:1848698-Vaccinia virus,
pubmed-meshheading:1848698-Viral Vaccines
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pubmed:year |
1991
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pubmed:articleTitle |
Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide.
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pubmed:affiliation |
Division of Immunology, The Netherlands Cancer Institute, Amsterdam.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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