18486988

Source:http://linkedlifedata.com/resource/pubmed/id/18486988

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0332197, umls-concept:C0596611, umls-concept:C1266101
pubmed:issue	3
pubmed:dateCreated	2008-12-2
pubmed:abstractText	Overexpression of KIT, a tyrosine kinase receptor protein encoded by the proto-oncogene c-kit, is observed in human neoplasms such as gastrointestinal stromal tumors (GISTs), myeloproliferative disorders, melanoma and seminoma. In patients with GIST, overexpression of mutated KIT within the tumor is predictive of response to molecular targeted therapy using imatinib. However, the role of KIT expression in thymic carcinoma is not fully understood.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8800805
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-kit
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	0169-5002
pubmed:author	pubmed-author:EimotoTadaakiT, pubmed-author:HashimotoTakehisaT, pubmed-author:HayashiJun-ichJI, pubmed-author:HosakaYasukoY, pubmed-author:KoikeTerumotoT, pubmed-author:ShinoharaHirohikoH, pubmed-author:TsuchidaMasanoriM, pubmed-author:UmezuHajimeH
pubmed:issnType	Print
pubmed:volume	62
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	321-5
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:18486988-Adenocarcinoma, pubmed-meshheading:18486988-Adolescent, pubmed-meshheading:18486988-Adult, pubmed-meshheading:18486988-Aged, pubmed-meshheading:18486988-Carcinoma, Adenosquamous, pubmed-meshheading:18486988-Carcinoma, Squamous Cell, pubmed-meshheading:18486988-DNA Mutational Analysis, pubmed-meshheading:18486988-Female, pubmed-meshheading:18486988-Gene Expression Regulation, Neoplastic, pubmed-meshheading:18486988-Humans, pubmed-meshheading:18486988-Immunoenzyme Techniques, pubmed-meshheading:18486988-Male, pubmed-meshheading:18486988-Middle Aged, pubmed-meshheading:18486988-Mutation, pubmed-meshheading:18486988-Neoplasm Staging, pubmed-meshheading:18486988-Polymerase Chain Reaction, pubmed-meshheading:18486988-Prognosis, pubmed-meshheading:18486988-Proto-Oncogene Proteins c-kit, pubmed-meshheading:18486988-Thymoma, pubmed-meshheading:18486988-Thymus Neoplasms, pubmed-meshheading:18486988-Young Adult
pubmed:year	2008
pubmed:articleTitle	Absence of gene mutations in KIT-positive thymic epithelial tumors.
pubmed:affiliation	Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan. kentsuchi@hotmail.com
pubmed:publicationType	Journal Article