|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0007776,
umls-concept:C0010453,
umls-concept:C0019564,
umls-concept:C0022655,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0063684,
umls-concept:C0086418,
umls-concept:C0237876,
umls-concept:C0443252,
umls-concept:C0871161
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|
pubmed:issue |
15
|
|
pubmed:dateCreated |
2008-6-16
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|
pubmed:abstractText |
Type 2 diabetes mellitus (DM) and Alzheimer's disease (AD) share epidemiological and biochemical features. Both are characterized by insoluble protein aggregates with a fibrillar conformation--amylin in Type 2 DM pancreatic islets, and Abeta in AD brain. To determine whether amylin shares neurotoxic properties with Abeta, we incubated hippocampal and cortical neurons with Abeta42 and human amylin. Different from non-amyloidogenic rat amylin, both caused a dose-, time- and cell type-specific neurotoxicity supporting the notion of a similar toxic mechanism. Depending on the cell type, this finding is also supported by co-incubation of human amylin and Abeta.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jun
|
|
pubmed:issn |
0014-5793
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
25
|
|
pubmed:volume |
582
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2188-94
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18486611-Amino Acid Sequence,
pubmed-meshheading:18486611-Amyloid,
pubmed-meshheading:18486611-Amyloid beta-Peptides,
pubmed-meshheading:18486611-Animals,
pubmed-meshheading:18486611-Cells, Cultured,
pubmed-meshheading:18486611-Cerebral Cortex,
pubmed-meshheading:18486611-Hippocampus,
pubmed-meshheading:18486611-Humans,
pubmed-meshheading:18486611-Islet Amyloid Polypeptide,
pubmed-meshheading:18486611-Molecular Sequence Data,
pubmed-meshheading:18486611-Neurons,
pubmed-meshheading:18486611-Peptide Fragments,
pubmed-meshheading:18486611-Rats
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|
pubmed:year |
2008
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|
pubmed:articleTitle |
Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures.
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|
pubmed:affiliation |
Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
