Linked Life Data

18485506

Source:http://linkedlifedata.com/resource/pubmed/id/18485506

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-6-13
pubmed:abstractText
The aim of the present study was to better understand the cortical structures and neuronal processes involved in aversive differential trace conditioning in healthy subjects. According to previous findings in literature, we tested whether the stimulus preceding negativity (SPN) in an emotional trace-conditioning paradigm shows a frontocentral maximum reflecting affective anticipation, e.g. in the anterior cingulate, or a centroparietal maximum reflecting time estimation and sensory anticipation. Two distinct SPN intervals were analyzed, one during the presentation of the CS (comparable to delay conditioning) and another one after CS offset (trace conditioning). In the CS+ condition, where subjects anticipated the onset of an aversive electrical stimulus after CS+ offset, a significantly larger negativity than in the unpaired (CS-) condition was present. SPN revealed a sustained midcentral and posterior parietal negativity during both SPN intervals. Differences between the two analyzed SPN intervals pointed towards occipital activity being found in the first interval (delay), but not in the second (trace). Aversive conditioning paradigms with longer trace intervals seem to rely upon a similar activation pattern as cognitive stimulus anticipation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0167-8760
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-51
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Slow cortical potentials in human aversive trace conditioning.
pubmed:affiliation
Section for Experimental Psychopathology, Psychiatric Hospital, University of Heidelberg, Vossstrasse 2, D-69115 Heidelberg, Germany. Stefanie.Hellwig@med.uni-heidelberg.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't