Source:http://linkedlifedata.com/resource/pubmed/id/18485429
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2008-6-16
|
| pubmed:abstractText |
Data on the relationship between the two genotypes of Giardia duodenalis that infect humans, assemblages A and B, their clinical presentation and intestinal inflammation are limited. We analyzed 108 stool samples previously collected for a diarrhoeal study among Brazilian children, representing 71 infections in 47 children. Assemblage B was most prevalent, accounting for 43/58 (74.1%) infections, while assemblage A accounted for 9/58 (15.5%) infections and 6/58 (10.3%) infections were mixed (contained both assemblage A and B). There was no significant difference in diarrhoeal symptoms experienced during assemblage A, B or mixed infections. Children with assemblage B demonstrated greater variability in G. duodenalis cyst shedding but at an overall greater level (n=43, mean 3.6 x 10(5), range 5.3 x 10(2)-2.5 x 10(6)cysts/ml) than children infected with assemblage A (n=9, mean 1.4 x 10(5), range 1.5 x 10(4)-4.6 x 10(5)cysts/ml; P=0.009). Children with mixed infections shed more cysts (mean 8.3 x 10(5), range 3.1 x 10(4)-2.8 x 10(6)cysts/ml) than children with assemblage A or B alone (P=0.069 and P=0.046 respectively). This higher rate of cyst shedding in children with assemblage B may promote its spread, accounting for its increased incidence. Additionally, second and third infections had decreasing faecal lactoferrin, suggesting some protection against severity, albeit not against infection, by prior infection.
|
| pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/T32 AI 007046,
http://linkedlifedata.com/resource/pubmed/grant/U01 AI 026512,
http://linkedlifedata.com/resource/pubmed/grant/U01 AI026512-100001,
http://linkedlifedata.com/resource/pubmed/grant/U54 AI 57168,
http://linkedlifedata.com/resource/pubmed/grant/U54 AI057168-010005
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0035-9203
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
102
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
718-25
|
| pubmed:dateRevised |
2010-12-3
|
| pubmed:meshHeading |
pubmed-meshheading:18485429-Animals,
pubmed-meshheading:18485429-Antigens, Protozoan,
pubmed-meshheading:18485429-Brazil,
pubmed-meshheading:18485429-Child, Preschool,
pubmed-meshheading:18485429-DNA, Protozoan,
pubmed-meshheading:18485429-Diarrhea,
pubmed-meshheading:18485429-Escherichia coli,
pubmed-meshheading:18485429-Feces,
pubmed-meshheading:18485429-Female,
pubmed-meshheading:18485429-Genotype,
pubmed-meshheading:18485429-Giardia,
pubmed-meshheading:18485429-Giardiasis,
pubmed-meshheading:18485429-Host-Parasite Interactions,
pubmed-meshheading:18485429-Humans,
pubmed-meshheading:18485429-Infant,
pubmed-meshheading:18485429-Longitudinal Studies,
pubmed-meshheading:18485429-Male,
pubmed-meshheading:18485429-Polymerase Chain Reaction,
pubmed-meshheading:18485429-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:18485429-Poverty Areas,
pubmed-meshheading:18485429-Sensitivity and Specificity,
pubmed-meshheading:18485429-Sequence Analysis, DNA
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Giardia duodenalis assemblage, clinical presentation and markers of intestinal inflammation in Brazilian children.
|
| pubmed:affiliation |
Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA. akohli@virginia.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|