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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1991-4-24
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pubmed:databankReference |
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pubmed:abstractText |
The murine GABAA/benzodiazepine (GABAA/BZ) receptor alpha 1 subunit cDNA has been isolated from a BALB/c mouse brain library and sequenced. The cDNA is 2665 nucleotides long with an open reading frame of 455 amino acids. It shows significant homology to the GABAA receptor alpha 1 subunit cDNA sequences of other species. Excluding deletions, the murine GABAA alpha 1 receptor exhibits 96% nucleotide and 100% amino acid sequence homology to the rat alpha 1 receptor cDNA and over 91% nucleotide and 98% amino acid sequence homology to the bovine and human alpha 1 receptor cDNAs in the protein coding region. This murine cDNA was used to locate the alpha 1 receptor subunit gene, Gabra-1, to murine Chromosome 11 between Il-3 and Rel. This assignment extends proximally the segment of mouse Chromosome 11 with known homology to human chromosome 5.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
390-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1848528-Amino Acid Sequence,
pubmed-meshheading:1848528-Animals,
pubmed-meshheading:1848528-Base Sequence,
pubmed-meshheading:1848528-Benzodiazepines,
pubmed-meshheading:1848528-Chromosome Mapping,
pubmed-meshheading:1848528-Crosses, Genetic,
pubmed-meshheading:1848528-Humans,
pubmed-meshheading:1848528-Mice,
pubmed-meshheading:1848528-Molecular Sequence Data,
pubmed-meshheading:1848528-Receptors, GABA-A,
pubmed-meshheading:1848528-Sequence Homology, Nucleic Acid
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pubmed:year |
1991
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pubmed:articleTitle |
The cDNA sequence and chromosomal location of the murine GABAA alpha 1 receptor gene.
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pubmed:affiliation |
Department of Pharmacology, Alcohol Research Center, University of Colorado Health Sciences Center, Denver.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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