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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-7-8
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pubmed:abstractText |
Plasma von Willebrand factor (VWF) is mainly derived from endothelial cells, cells that express a large repertoire of genes that are transcriptionally regulated by fluid shear stress. Endothelial VWF expression is not uniform throughout the vasculature, and levels are increased at regions associated with disturbed blood flow and steep gradients of shear stress. It is, however, unknown whether shear stress influences the regulation of VWF gene expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1538-7836
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1183-90
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18485092-Animals,
pubmed-meshheading:18485092-Cattle,
pubmed-meshheading:18485092-Cells, Cultured,
pubmed-meshheading:18485092-Endothelial Cells,
pubmed-meshheading:18485092-Gene Expression Regulation,
pubmed-meshheading:18485092-Humans,
pubmed-meshheading:18485092-Mice,
pubmed-meshheading:18485092-Mutagenesis, Site-Directed,
pubmed-meshheading:18485092-Polymorphism, Single Nucleotide,
pubmed-meshheading:18485092-Promoter Regions, Genetic,
pubmed-meshheading:18485092-RNA, Messenger,
pubmed-meshheading:18485092-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:18485092-Stress, Mechanical,
pubmed-meshheading:18485092-Transcriptional Activation,
pubmed-meshheading:18485092-Transfection,
pubmed-meshheading:18485092-Umbilical Veins,
pubmed-meshheading:18485092-von Willebrand Factor
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pubmed:year |
2008
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pubmed:articleTitle |
Influence of a GT repeat element on shear stress responsiveness of the VWF gene promoter.
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pubmed:affiliation |
Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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