Linked Life Data

18484599

Source:http://linkedlifedata.com/resource/pubmed/id/18484599

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2008-6-24
pubmed:abstractText
Dmitrienko et al. (Statist. Med. 2007; 26:2465-2478) proposed a tree gatekeeping procedure for testing logically related hypotheses in hierarchically ordered families, which uses weighted Bonferroni tests for all intersection hypotheses in a closure method by Marcus et al. (Biometrika 1976; 63:655-660). An algorithm was given to assign weights to the hypotheses for every intersection. The purpose of this note is to show that any weight assignment algorithm that satisfies a set of sufficient conditions can be used in this procedure to guarantee gatekeeping and independence properties. The algorithm used in Dmitrienko et al. (Statist. Med. 2007; 26:2465-2478) may fail to meet one of the conditions, namely monotonicity of weights, which may cause it to violate the gatekeeping property. An example is given to illustrate this phenomenon. A modification of the algorithm is shown to rectify this problem.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0277-6715
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3446-51
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
A note on tree gatekeeping procedures in clinical trials.
pubmed:affiliation
Eli Lilly and Company, Indianapolis, IN 46285, USA. dmitrienko_alex@lilly.com
pubmed:publicationType
Journal Article, Comment, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural