Source:http://linkedlifedata.com/resource/pubmed/id/18484082
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-1-27
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| pubmed:abstractText |
Variability in antidepressant response is due to genetic and environmental factors. Among genetic factors, the ones controlling for availability of the drug at the target site are interesting candidates. Rs6295C/G SNP in the 5-HT1A gene (HTR1A) has been found to affect the expression and function of HTR1A. In fact rs6295C/G is in strong linkage disequilibrium with other polymorphisms of HTR1A suggesting that those functional effects could be associated with polymorphisms other than or together with the synonymous rs6295C/G. In the present study we examined the possible association of a panel of markers in strong linkage disequilibrium of the HTR1A with SSRI/SNRI response in 137 Japanese major depression subjects followed for 6 weeks. We observed a significant association of better response to antidepressant in rs10042486C/C (P < 0.0001), rs6295G/G (P < 0.0001) and rs1364043T/T (P = 0.018) genotype carriers (minor allele homozygotes), independently from clinical variables. Furthermore minor allele homozygous carriers in all these three SNPs were associated with treatment response by various assessment such as HAM-D score change over time (P = 0.001), week 2 (P < 0.0001), 4 (P = 0.007), and 6 (P = 0.048) as well as response rate (P = 0.0005) and remission rate (P = 0.004). We also pointed out the genotyping mis-definition of rs6295C/G in the previous four articles. In conclusion, this is the first study that reports a significant association of antidepressant response with rs10042486C/T and rs1364043T/G variants of HTR1A and also with rs10042486-rs6295-rs1364043 combination. This finding adds an important information for the pathway of detecting the genetics of antidepressant response even if results must be verified on larger samples.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1552-485X
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| pubmed:author |
pubmed-author:AzumaJunichiJ,
pubmed-author:FukudaTsuyoshiT,
pubmed-author:HosoiYukaY,
pubmed-author:KatoMasakiM,
pubmed-author:KinoshitaToshihikoT,
pubmed-author:OkugawaGakuG,
pubmed-author:SerrettiAlessandroA,
pubmed-author:TakekitaYoshiteruY,
pubmed-author:WakenoMasatakaM,
pubmed-author:WatanabeSyunsukeS,
pubmed-author:YamashitaMegumiM
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| pubmed:copyrightInfo |
2008 Wiley-Liss, Inc.
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| pubmed:issnType |
Electronic
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| pubmed:day |
5
|
| pubmed:volume |
150B
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
115-23
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| pubmed:meshHeading |
pubmed-meshheading:18484082-Antidepressive Agents, Second-Generation,
pubmed-meshheading:18484082-Base Sequence,
pubmed-meshheading:18484082-DNA Primers,
pubmed-meshheading:18484082-Depressive Disorder, Major,
pubmed-meshheading:18484082-Humans,
pubmed-meshheading:18484082-Linkage Disequilibrium,
pubmed-meshheading:18484082-Polymorphism, Single Nucleotide,
pubmed-meshheading:18484082-Receptor, Serotonin, 5-HT1A,
pubmed-meshheading:18484082-Serotonin Uptake Inhibitors
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| pubmed:year |
2009
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| pubmed:articleTitle |
Effect of 5-HT1A gene polymorphisms on antidepressant response in major depressive disorder.
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| pubmed:affiliation |
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan. masaki.kato@unibo.it
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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