|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2008-5-16
|
|
pubmed:abstractText |
To modulate intracellular ceramide levels and lower the apoptotic threshold in multidrug-resistant ovarian adenocarcinoma, we have examined the efficacy and preliminary safety of tamoxifen coadministration with paclitaxel in biodegradable poly(ethylene oxide)-modified poly(epsilon-caprolactone) (PEO-PCL) nanoparticles.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1078-0432
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3193-203
|
|
pubmed:meshHeading |
pubmed-meshheading:18483388-Adenocarcinoma,
pubmed-meshheading:18483388-Animals,
pubmed-meshheading:18483388-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:18483388-Cell Line, Tumor,
pubmed-meshheading:18483388-Ceramides,
pubmed-meshheading:18483388-Cytoplasm,
pubmed-meshheading:18483388-Drug Delivery Systems,
pubmed-meshheading:18483388-Drug Resistance, Multiple,
pubmed-meshheading:18483388-Drug Resistance, Neoplasm,
pubmed-meshheading:18483388-Female,
pubmed-meshheading:18483388-Humans,
pubmed-meshheading:18483388-In Situ Nick-End Labeling,
pubmed-meshheading:18483388-Mice,
pubmed-meshheading:18483388-Mice, Nude,
pubmed-meshheading:18483388-Nanoparticles,
pubmed-meshheading:18483388-Ovarian Neoplasms,
pubmed-meshheading:18483388-Paclitaxel,
pubmed-meshheading:18483388-Polyesters,
pubmed-meshheading:18483388-Polyethylene Glycols,
pubmed-meshheading:18483388-Selective Estrogen Receptor Modulators,
pubmed-meshheading:18483388-Tamoxifen
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Modulation of drug resistance in ovarian adenocarcinoma by enhancing intracellular ceramide using tamoxifen-loaded biodegradable polymeric nanoparticles.
|
|
pubmed:affiliation |
Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
