rdf:type |
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0030705,
umls-concept:C0040649,
umls-concept:C0040661,
umls-concept:C0185117,
umls-concept:C0205210,
umls-concept:C0278701,
umls-concept:C1274040,
umls-concept:C1708567,
umls-concept:C1710082,
umls-concept:C1826565,
umls-concept:C2911684
|
pubmed:issue |
10
|
pubmed:dateCreated |
2008-5-16
|
pubmed:abstractText |
Raf Kinase Inhibitory Protein (RKIP) plays a pivotal role in cancer by regulating apoptosis induced by chemotherapeutic agents, or immune-mediated stimuli and is a metastasis suppressor protein. The signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is frequently activated in gastric adenocarcinomas, thereby promoting tumor growth. We examined the expression patterns of RKIP and STAT3 with regard to human gastric cancer, predicting that elevated RKIP status may favor clinical outcome.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1078-0432
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2994-3001
|
pubmed:dateRevised |
2010-11-18
|
pubmed:meshHeading |
pubmed-meshheading:18483365-Adenocarcinoma,
pubmed-meshheading:18483365-Adult,
pubmed-meshheading:18483365-Aged,
pubmed-meshheading:18483365-Aged, 80 and over,
pubmed-meshheading:18483365-Female,
pubmed-meshheading:18483365-Gene Expression,
pubmed-meshheading:18483365-Humans,
pubmed-meshheading:18483365-Immunohistochemistry,
pubmed-meshheading:18483365-Kaplan-Meier Estimate,
pubmed-meshheading:18483365-Male,
pubmed-meshheading:18483365-Middle Aged,
pubmed-meshheading:18483365-Phosphatidylethanolamine Binding Protein,
pubmed-meshheading:18483365-Prognosis,
pubmed-meshheading:18483365-STAT3 Transcription Factor,
pubmed-meshheading:18483365-Stomach Neoplasms,
pubmed-meshheading:18483365-Tissue Array Analysis,
pubmed-meshheading:18483365-Tumor Markers, Biological
|
pubmed:year |
2008
|
pubmed:articleTitle |
Inverse association between Raf Kinase Inhibitory Protein and signal transducers and activators of transcription 3 expression in gastric adenocarcinoma patients: implications for clinical outcome.
|
pubmed:affiliation |
Department of Medicine, Rhode Island Hospital, Providence, Rhode Island 02903, USA. dchatter@lifespan.org
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|