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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-5-16
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pubmed:abstractText |
[(11)C](R)-Rolipram is a selective radioligand for positron emission tomography (PET) imaging of phosphodiesterase 4, an enzyme that metabolizes 3',5'-cyclic adenosine monophosphate. The aim of this study was to estimate the human radiation absorbed dose of the radioligand based on its biodistribution in both monkeys and humans.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-10025682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-10768560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-11395307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-11746724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-12180273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-12458404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-15937315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-15961054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-16190900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-17204705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-2669364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-2906101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-3400274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-8070581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-8104129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-8310711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-9236543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-9311927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18482687-9880581
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0969-8051
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
493-500
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18482687-Animals,
pubmed-meshheading:18482687-Carbon Radioisotopes,
pubmed-meshheading:18482687-Cyclic Nucleotide Phosphodiesterases, Type 4,
pubmed-meshheading:18482687-Haplorhini,
pubmed-meshheading:18482687-Humans,
pubmed-meshheading:18482687-Metabolic Clearance Rate,
pubmed-meshheading:18482687-Phosphodiesterase 4 Inhibitors,
pubmed-meshheading:18482687-Positron-Emission Tomography,
pubmed-meshheading:18482687-Radiation Dosage,
pubmed-meshheading:18482687-Radiopharmaceuticals,
pubmed-meshheading:18482687-Rolipram,
pubmed-meshheading:18482687-Tissue Distribution,
pubmed-meshheading:18482687-Whole Body Imaging,
pubmed-meshheading:18482687-Whole-Body Counting
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pubmed:year |
2008
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pubmed:articleTitle |
Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [(11)C](R)-rolipram: comparison of two-dimensional planar, bisected and quadrisected image analyses.
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pubmed:affiliation |
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892-2035, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Intramural
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