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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-5-16
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pubmed:abstractText |
Since the late 1980s, cocaine analogues based on the phenyltropane structure, such as [(11)C]CFT and [(123)I]beta-CIT have been used for the imaging of the dopamine transporter. FE@CIT (fluoropropyl ester) and FP-CIT (N-fluoropropyl derivative) are further analogues. The aim of this study was to (1) evaluate and compare the metabolic stability of beta-CIT, FP-CIT and FE@CIT against carboxyl esterases and (2) evaluate selectivity of [(18)F]FE@CIT compared to [(123)I]beta-CIT and [(123)I]FP-CIT using autoradiography.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-carbomethoxy-8-(3-fluoropropyl)-3-...,
http://linkedlifedata.com/resource/pubmed/chemical/3-amino-4-(2-dimethylaminomethylphen...,
http://linkedlifedata.com/resource/pubmed/chemical/Aniline Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Carboxylesterase,
http://linkedlifedata.com/resource/pubmed/chemical/Cocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Fluoxetine,
http://linkedlifedata.com/resource/pubmed/chemical/N-(2-fluoroethyl)-2-carbomethoxy-3-(...,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Nortropanes,
http://linkedlifedata.com/resource/pubmed/chemical/RTI 55,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Uptake Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfides,
http://linkedlifedata.com/resource/pubmed/chemical/Tropanes,
http://linkedlifedata.com/resource/pubmed/chemical/nisoxetine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0969-8051
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pubmed:author |
pubmed-author:DudczakRobertR,
pubmed-author:EttlingerDagmar EDE,
pubmed-author:GirscheleFriedrichF,
pubmed-author:HäuslerDanielaD,
pubmed-author:KletterKurtK,
pubmed-author:MienLeonhard-KeyLK,
pubmed-author:MitterhauserMarkusM,
pubmed-author:SindelarKaroline MKM,
pubmed-author:UngersböckJohannaJ,
pubmed-author:ViernsteinHelmutH,
pubmed-author:WadsakWolfgangW
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
475-9
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pubmed:meshHeading |
pubmed-meshheading:18482685-Aniline Compounds,
pubmed-meshheading:18482685-Animals,
pubmed-meshheading:18482685-Autoradiography,
pubmed-meshheading:18482685-Binding, Competitive,
pubmed-meshheading:18482685-Carboxylesterase,
pubmed-meshheading:18482685-Cocaine,
pubmed-meshheading:18482685-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:18482685-Drug Stability,
pubmed-meshheading:18482685-Fluoxetine,
pubmed-meshheading:18482685-Kinetics,
pubmed-meshheading:18482685-Male,
pubmed-meshheading:18482685-Norepinephrine Plasma Membrane Transport Proteins,
pubmed-meshheading:18482685-Nortropanes,
pubmed-meshheading:18482685-Rats,
pubmed-meshheading:18482685-Rats, Wistar,
pubmed-meshheading:18482685-Serotonin Uptake Inhibitors,
pubmed-meshheading:18482685-Sulfides,
pubmed-meshheading:18482685-Tropanes
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pubmed:year |
2008
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pubmed:articleTitle |
Metabolism and autoradiographic evaluation of [(18)F]FE@CIT: a Comparison with [(123)I]beta-CIT and [(123)I]FP-CIT.
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pubmed:affiliation |
Department of Nuclear Medicine, Medical University of Vienna, A-1090 Vienna, Austria.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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