Source:http://linkedlifedata.com/resource/pubmed/id/18482353
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
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| pubmed:dateCreated |
2008-9-16
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| pubmed:abstractText |
Recombinant human bone morphogenetic protein-2 has been shown to promote bone formation because of its osteoinductive property. The purpose of this study was to evaluate the efficacy of rhBMP-2 delivered on a poly (D, L-lactic-co-glycolic acid) copolymer/gelatin sponge (PGS) in vertical alveolar ridge augmentation on height-reduced edentulous mandible to verify the retention of rhBMP-2 withstanding the pressure of soft tissues. Coronal defects of the alveolar bone were created in six adult beagle dogs. After a healing period of 9 weeks, PGSs with or without rhBMP-2 (0 or 0.4 mg mL(-1)) were implanted on the defects(6 mm in height, 30 mm in length, 8 mm in width). Sixteen weeks after implantation, the bone mineral content (BMC) and the total bone area were measured by peripheral quantitative computed tomography. The BMC and the total bone area of the defect sites with rhBMP-2 group were significantly greater (133+/-33 mg mm(-1), 277+/-54 mm2, respectively) than those of the control group (80+/-19 mg mm(-1), 155+/-49 mm2, respectively) (P<0.01, P<0.0001, respectively; paired t-test). From the histological analyses, the height of newly formed bone in the experimental group was greater than that of the control group (4.3+/-0.9 mm, 0.22+/-0.28 mm, P<0.0001, n=6, paired t-test). These results indicate that PGS has characteristics of effective bone graft substitutes for implantation of rhBMP-2 on vertical alveolar ridge augmentation in huge defect of mandibles in dogs.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
D
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Carriers,
http://linkedlifedata.com/resource/pubmed/chemical/Gelatin,
http://linkedlifedata.com/resource/pubmed/chemical/Lactic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Polyglycolic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/polylactic acid-polyglycolic acid...,
http://linkedlifedata.com/resource/pubmed/chemical/recombinant human bone...
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1365-2842
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
35
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
647-55
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:18482353-Alveolar Ridge Augmentation,
pubmed-meshheading:18482353-Animals,
pubmed-meshheading:18482353-Biocompatible Materials,
pubmed-meshheading:18482353-Biomechanics,
pubmed-meshheading:18482353-Bone Density,
pubmed-meshheading:18482353-Bone Morphogenetic Protein 2,
pubmed-meshheading:18482353-Bone Morphogenetic Proteins,
pubmed-meshheading:18482353-Bone Regeneration,
pubmed-meshheading:18482353-Dogs,
pubmed-meshheading:18482353-Drug Carriers,
pubmed-meshheading:18482353-Gelatin,
pubmed-meshheading:18482353-Lactic Acid,
pubmed-meshheading:18482353-Male,
pubmed-meshheading:18482353-Mandible,
pubmed-meshheading:18482353-Polyglycolic Acid,
pubmed-meshheading:18482353-Recombinant Proteins,
pubmed-meshheading:18482353-Tomography, X-Ray Computed,
pubmed-meshheading:18482353-Transforming Growth Factor beta,
pubmed-meshheading:18482353-Wound Healing
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| pubmed:year |
2008
|
| pubmed:articleTitle |
Effect of rhBMP-2 with PLGA/gelatin sponge type (PGS) carrier on alveolar ridge augmentation in dogs.
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| pubmed:affiliation |
Section of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. Noriko.peri@tmd.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Validation Studies
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