Linked Life Data

18481030

Source:http://linkedlifedata.com/resource/pubmed/id/18481030

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-5-15
pubmed:abstractText
Lipoxins (LXs) are endogenously produced eicosanoids that are typically generated by transcellular biosynthesis. These trihydroxytetraene-containing lipid mediators and their stable synthetic analogues possess a wide spectrum of anti-inflammatory and pro-resolution bioactions both in vitro and in vivo. More recently, LXs have emerged as potential anti-fibrotic mediators that may influence pro-fibrotic cytokines and matrix-associated gene expression in response to platelet-derived growth factor (PDGF). Here we review the biosynthesis, metabolism and bioactions of LXs and LX analogues and their therapeutic potential.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0303-4240
pubmed:author
pubmed:issnType
Print
pubmed:volume
160
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-70
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Lipoxins: update and impact of endogenous pro-resolution lipid mediators.
pubmed:affiliation
UCD Conway Institute of Biomolecular and Biomedical Research and UCB Diabetes Research Center, School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin 4, Ireland.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't